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Rivista sulle Malattie del Sistema Endocrino


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Minerva Endocrinologica 2017 Mar 01

DOI: 10.23736/S0391-1977.17.02551-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Comparison of curative effect of 131I and antithyroid drugs in Graves’ disease: a meta analysis

Ju YUAN 1, Xiuqing LU 2, Yan YUE 1

1 Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou, China; 2 Department of Neurology, Henan Province Hospital of TCM, Zhengzhou, China


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BACKGROUND: Radioactive 131I is currently reported to be a potential effective intervention for Graves’ Disease treatment in China. Whether 131I treatment was associated with effective outcome or reduced risk of side effects, reccurence rate remained unknown.
EVIDENCE ACQUISITION: Eligible studies were selected from Chinese VIP, Wangfang, CNKI databases using the keywords “Iodine” and “Graves Disease”. Finally, 13 clinical trials met the inclusion criterion and were included this meta-analysis.
EVIDENCE SYNTHESIS: Our meta-analysis included 1355 patients diagnosed of Graves’ Disease with regular anti-thyroid drugs oral administration and 1320 patients with 131I therapy. The results showed that there was significant symptom improvement with radioactive iodine intervention (Odd Ratio (OR)=4.50, 95% CI [3.55, 5.71], P<0.01). 3 studies mentioned side effects, 6 mentioned reccurence rate and another 6 mentioned hypothyroidism. The ORs and 95%CIs for these subgroups were 0.12 [0.06, 0.21], 0.08 [0.05, 0.13] and 2.27 [1.77, 2.92] respectively. It means a significant reduction of side effects and reccurence rate but increased hypothyroidism after 131I intervention in Graves’ Disease.
CONCLUSION: Treatment with 131I was associated with better clinical outcome; it reduced side effects and reccurence rate but increased hypothyroidism in Graves’ Disease.


KEY WORDS: 131I - Antithyroid drugs - Grave's disease - Meta-analysis - Clinic outcome

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Yuan J, Lu X, Yue Y. Comparison of curative effect of 131I and antithyroid drugs in Graves’ disease: a meta analysis. Minerva Endocrinol 2017 Mar 01. DOI: 10.23736/S0391-1977.17.02551-2 

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m_x_h726@sina.com