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Minerva Endocrinologica 2016 Jul 13

lingua: Inglese

Novel perspectives on hypothalamic-pituitary dysfunction as a risk factor for nonalcoholic fatty liver disease

Anika HOFFMANN, Hermann L. MüLLER

Department of Pediatrics, Klinikum Oldenburg, Medical Campus University Oldenburg, Oldenburg, Germany


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INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) presents a disease with a wide spectrum spanning from benign steatosis to steatohepatitis with fibrosis and scarring that can lead to cirrhosis. With increasing prevalence, NAFLD is developing into the leading indication for liver transplantation worldwide. Disturbances in endocrine, hypothalamic-pituitary axes have been associated with NALFD, including GH deficiency, hypothyroidism, hypercortisolaemia, and hypogonadism.
EVIDENCE OF ACQUISITION AND SYNTHESIS: In this review, we examine the published data (search: PUBMED, 1990–2016) suggesting a link between endocrine abnormalities of hypothalmic-pituitary axes and NAFLD and summarise the clinical data on risk factors for NAFLD in specific diseases involving hypothalmic-pituitary axes.
CONCLUSIONS: Hormonal substitution of endocrine deficiencies has been shown to have beneficial effects at least in some instances. While the association between type 2 diabetes and NAFLD is well known, there is rather limited appreciation of the condition among common endocrine diseases involving hypothalamic-pituitary axes. In diseases involving hypothalamic-pituitary areas and manifesting clinically with endocrine deficiencies of hypothalamic-pituitary axes such as childhood- onset craniopharyngioma NAFLD is a frequent sequela of hypothalmic obesity.

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mueller.hermann@klinikum-oldenburg.de