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Minerva Endocrinologica 2014 Jul 08


lingua: Inglese

Emergence of SFRP5 as a pleiotropic adipocytokine and its association with Wnt signaling

Jaikanth C. 1, Gurumurthy P. 1, Indhumathi T. 2, Cherian K. M. 3

1 Department of Biochemical Pharmacology, Frontier Lifeline Hospital & Dr. K M Cherian Heart Foundation, Mogappair, Chennai, Tamilnadu, India;
2 Medical Officer, Take Care Hospital Private limited, Chennai, Tamilnadu, India;
3 Department of Cardiology, Frontier Lifeline Hospital & Dr. K M Cherian Heart Foundation, Mogappair, Chennai, Tamilnadu, India


The status of being a non communicable disease held by obesity is slowly fading. It is gaining a more contagious, literally communicable and deadly status. The downstream co-­morbidities associated with it are endless. Hence the world is promoting the slogan “FAT TO FIT”. The view on the white adipose tissue as a fat storage organ is now being changed to an endocrine organ. The secreted hormones are called adipocytokines which act in an autocrine/paracine/endocrine fashion to exhibit its effects. Like any hormone it has positive as well as negative influence over the body. SFRP5 is a recently identified novel adipocytokine and it falls under the category of being a good adipokine proving a positive influence. Plasma SFRP5 levels are significantly decreased in patients with obesity, insulin resistance and diabetes that contribute to the major components of the metabolic syndrome and other disease conditions like atherosclerosis, autoimmune disorders etc. This review article focuses on the comprehensive effects of SFRP5 on all the major systems of the body and its association with the Wnt signalling pathways.

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