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Minerva Endocrinologica 2016 September;41(3):291-7

lingua: Inglese

Association between retinol binding protein 4 with atherosclerotic markers in obese children

Nalini SANTANAM 1, Yoram ELITSUR 2, Ronald STANEK 3, Mateen HOTIANA 3, Jennifer WHEATON 3, Reem KHEETAN 3, Randa ALJAYOUSSI 3, Todd GRESS 3, Abid YAQUB 3

1 Department of Pharmacology, Physiology and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA; 2 Section of Pediatric Gastroenterology Department of Pediatrics, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA; 3 Department of Internal Medicine, Section of Endocrinology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA


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BACKGROUND: Childhood obesity increases cardiovascular risk during adulthood. Retinol-binding protein-4, a pro-inflammatory adipokine, associated with obesity and insulin resistance also plays a role in atherogenesis in adults. The goal of this study was to identify the relation between RBP4 and atherogenic markers in obese children.
METHODS: In a cross-sectional study, obese and non-obese children (8-18 years) were prospectively recruited from a pediatric Appalachian population. Clinical markers such as lipid profile, HbA1c, markers of insulin resistance and plasma levels of RBP4, sVCAM-1 and oxidized-low-density lipoprotein (Ox-LDL) were measured.
RESULTS: Compared to non-obese children, RBP4 (P=0.016) and Ox-LDL (P<0.001) were significantly higher in obese children and were positively correlated with Body Mass Index (P<0.001), BMI-SDS (Standard-Deviation Score) (P<0.001) and waist circumference (P=0.03).
CONCLUSIONS: No significant correlation was found between inflammatory markers and Homeostatic Model Assessment-2, HDL, triglycerides, and HbA1c in obese children.

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santanam@marshall.edu