Home > Riviste > Minerva Endocrinologica > Fascicoli precedenti > Minerva Endocrinologica 2016 Giugno;41(2) > Minerva Endocrinologica 2016 Giugno;41(2):157-65

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

MINERVA ENDOCRINOLOGICA

Rivista sulle Malattie del Sistema Endocrino


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118


eTOC

 

ORIGINAL ARTICLES  


Minerva Endocrinologica 2016 Giugno;41(2):157-65

lingua: Inglese

Elastosonography scoring and strain index of thyroid nodules with Hurthle cells

Dilek TUZUN 1, Reyhan ERSOY 2, Aylin KILICYAZGAN 3, Gülten KIYAK 4, Samet YALCIN 5, Bekir CAKIR 1

1 Department of Endocrinology and Metabolism, Ankara Atatürk Research and Training Hospital, Ankara, Turkey; 2 Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; 3 Department of Pathology, Ankara Atatürk Research and Training Hospital, Ankara, Turkey; 4 Department of General Surgery, Ankara Atatürk Research and Training Hospital, Ankara, Turkey; 5 Department of General Surgery, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey


PDF  


BACKGROUND: This study evaluated the effectiveness of elastosonography (ES) scoring and strain index (SI) in diagnosing patients with thyroid nodules composed primarily of Hurthle cells.
METHODS: This study retrospectively analyzed 57 patients with thyroid nodules composed predominantly of Hurthle cells on fine needle aspiration cytology (FNAC). Patients were evaluated by thyroid ultrasonography (US), ES scoring, SI, US guided FNAC, and histopathology.
RESULTS: Histopathologically, 12 (21.1%) nodules were malignant and 45 (78.9%) were benign. Mean age, sex distribution, thyroid function tests, and morphologic features on US were similar in the malignant and benign groups. Mean SI (40.98±31.28 vs 21.24±25.47, p=0.027) and thyroid peroxidase antibody (anti-TPOab) positivity (p=0.004) were significantly higher in malignant than in benign nodules. Receiver operating curve (ROC) analysis showed that an SI cutoff of 10.326 had a sensitivity of 91.7% and a specificity of 49%, and an SI cut-off of 64.807 had a specificity of 91.1% and a sensitivity of 25%. The optimal SI cut-off value, 17.877, had a sensitivity of 66.7%, a specificity of 66.7%, a positive predictive value (PPV) of 34.8%, a negative predictive value (NPV) of 88.2%, and an area under the ROC curve of 73.1±0.074% (95% CI: 58.7-87.6.5%). The sensitivity, specificity, PPV, NPV and diagnostic accuracy of ES scoring were 41.6%, 91.1%, 55.5%, 85.4% and 80.7%, respectively.
CONCLUSIONS: This is the first study to investigate ES scoring and SI in nodules composed predominantly of Hurthle cells on FNAC. ES scoring and SI may add some contribution to ultrasonography in the characterization of thyroid nodules with Hurthle cells.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

tuzund@gmail.com