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Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Jun LIU, Peishi FAN, Jun CHU, Jian YANG, Xiaohu YANG, Lu ZHANG, Guo CHUNLIANG
Affiliated Hospital of the Logistics University of Chinese People’s Armed Police Forces, Department of Hepatobiliary Surgery, Hedong District, Tianjin, China
BACKGROUND: To evaluate antimicrobial properties of Dermacyn in abdominal infections, and to develop a new method for peritoneal lavage without using antibiotics.
METHODS: 110 patients suffered from intestinal perforation (abdominal closed injury) who were treated with opened surgical repair or partial intestinal resection were enrolled in our test group. In the test group, Dermacyn was used for peritoneal lavage. During the same period, 102 patients with intestinal perforation of abdominal closed injury and opened repair or partial intestinal resection were enrolled in our control group. For the control group, we used Metronidazole physiological saline for peritoneal lavage. Patients in both groups had an indwelling peritoneal drainage tube postoperatively. Five objective indicators were studied and compared at 24 h/48 h/72 h time points. These indexes were: volume of drainage, drainage fluid culture, blood routine test, C-reactive protein, calcitonin and antibiotics dose.
RESULTS: There were no significant differences between the drainage volumes in two groups three days after the operation. There were significant differences in the nature of the drainage fluid, bacterial culture results, blood routine, C-reaction protein and procalciton in two groups. In the experimental group, after the Dermacyn flushing, the average volume of peritoneal drainage fluid was reduced (from 30 ml to 5 ml) from 24 to 72 hours postoperatively.
CONCLUSIONS: Use of Dermacyn, with its broad spectrum bactericidal effect, as the monantibiotic ingredient for intraoperative peritoneal lavage was effective in bringing down the risk of infection. Dermacyn could be used safely to perform peritoneal flushing to clean the operation site.