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Rivista di Chirurgia
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Chirurgica 2016 June;71(3):159-67
Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: results from a high-prevalence area
Gregorio SCERRINO 1, Andrea ATTARD 2, Giuseppina Irene MELFA 1, Cristina RASPANTI 1, Silvia DI GIOVANNI 1, Marco ATTARD 3, Angela INVIATI 1, Sergio MAZZOLA 4, Giuseppe MODICA 2, Gaspare GULOTTA1, Sebastiano BONVENTRE 1 ✉
1 Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery, P. Giaccone Policlinico, Palermo, Italy; 2 Section of General and Thoracic Surgery, Department of General, Emergency and Transplant Surgery, P. Giaccone Policlinico, Palermo, Italy; 3 Unit of Endocrinology, V. Cervello Hospital, Palermo, Italy; 4 Political Sciences Faculty, University of Palermo, Palermo, Italy
BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach.
METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed.
RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49%), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P<0.05; P<0.001, respectively). The median radioiodine ablative treatment in the T2 cluster alone was lower in group A (P<0.001). The morbidity rate was similar in both groups.
CONCLUSION: Considering the acceptable morbidity, prophylactic CND seems to be advantageous in terms of recurrence rate and need for radioiodine treatment in this variant of PTC, at least in T2 or more advanced stages. The indolent behavior of PTC does not allow for reliable prognostic evaluations.