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Minerva Chirurgica 2015 June;70(3):175-80

lingua: Inglese

Role of TachoSil® in distal pancreatectomy: a single center experience

Silvestri S. 1, Franchello A. 1, Gonella F. 1, Deiro G. 1, Campra D. 1, Cassine D. 1, Fiore A. 1, Ostuni E. 1, Garino M. 2, Resegotti A. 1, Farina E. C. 1, Fronda G. R. 1

1 4th General Surgery Department, A.O.U. Città della Salute e della Scienza, Turin, Italy;
2 Department of General Surgery, A.O. Ospedale di Rivoli, Rivoli, Turin, Italy


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AIM: Distal pancreatectomies (DP) are associated with high risk of postoperative complications, and in many series higher morbidity rate than duodenopancreatectomies has been reported. To evaluate the role of a collagen sponge with human fibrinogen and thrombin film (TachoSil®) in limiting the incidence of complications after DP.
METHODS: From 1996 to 2013, 221 patients have been submitted to distal pancreatectomy (+/- splenectomy) in our Division. A retrospective analysis has been conducted in a group of 36 consecutive and prospectively collected DP treated with intraoperative placement of TachoSil® on pancreatic stump from 2010 to 2013 (group 1). A control series of 36 consecutive patients (group 2) was matched 1:1 from hystorical database. The variables considered in the analysis were: age, gender, ASA score, pancreatic texture (hard vs. soft), histology, operative time, postoperative mortality, morbility (postoperative pancreatic fistula - POPF, postoperative hemorrage - PPH, delayed gastric emptying - DGE) and hospital stay. Differences between POPF, PPH, DGE and hospital stays between grops were investigated with χ2 and t-Student test. Univariate analysis was conducted to determine factors related to POPF development. Statistical analysis was performed using freeware Microsoft Excel based program.
RESULTS: Post operative mortality was 0% in both groups. POPF were registered in 36.1% (13/36) and 41.6 % (15/36) in groups 1 and 2, respectively (P=n.s.); in group 1 we didn’t observe grade C POPF, while 4 patients in control group developed grade C POPF (P<0,05). No differences were found between two groups in terms of incidence of PPH and DGE. The median duration of postoperative hospital stay in group 1 was 21.8 (7-189) days compared with 31.13 (9-249) days in group 2 (P<0.001).
CONCLUSION:The use of TachoSil® seems to be associated with lower incidence of grade C POPF but larger controlled trials are needed to surely assess the usefulness of TachoSil® in pancreatic surgery in order to reduce pancreatic specific complications and their severity.

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afranchello@cittadellasalute.to.it