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Rivista sulle Malattie del Cuore e dei Vasi

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2016 December;64(6):686-96

lingua: Inglese

Helicobacter pylori infection and ischemic heart disease: could experimental data lead to clinical studies?

Davide G. RIBALDONE 1, Sharmila FAGOONEE 2, Ingrid HICKMAN 3, Fiorella ALTRUDA 4, Giorgio M. SARACCO 1, 5, Rinaldo PELLICANO 1

1 Unit of Gastroenterology, Molinette Hospital, Turin, Italy; 2 Institute of Biostructure and Bioimaging (National Research Council), Molecular Biotechnology Center, University of Turin, Turin, Italy; 3 Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia; 4 Molecular Biotechnology Center, University of Turin, Turin, Italy; 5 Department of Oncology, University of Turin, Turin, Italy


Despite the remarkable advances made in primary prevention and treatment, ischemic heart disease (IHD) remains the leading cause of death and a significant cause of disability in developed countries. Since traditional cardiovascular risk factors failed to predict all cases of IHD, there is an intensive research to explore other potential etiologic factors. Among these, numerous studies have considered the theoretical link between IHD and chronic infections, including Helicobacter pylori (H. pylori). Considering that epidemiologic studies have produced conflicting results, due to geographical variations of IHD and H. pylori prevalence as well as heterogeneity of study designs, an alternative way to analyze this topic is to assess if consistency for a biological plausibility exists. In this review we critically analyzed the experimental data on this topic, to assess whether their results could lead future clinical studies.

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