Home > Riviste > Minerva Biotecnologica > Fascicoli precedenti > Minerva Biotecnologica 2015 September;27(3) > Minerva Biotecnologica 2015 September;27(3):149-57

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

MINERVA BIOTECNOLOGICA

Rivista di Biologia Molecolare e Biotecnologie


Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246


eTOC

 

REVIEWS  


Minerva Biotecnologica 2015 September;27(3):149-57

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Update on colonization, survival and antibiotic resistance of Helicobacter pylori at the molecular level

Rosso C. 1, Fagoonee S. 2, Altruda F. 3, Pellicano R. 1

1 Department of Gastroenterology and Hepatology, S. Giovanni Battista (Molinette) Hospital, Turin, Italy;
2 Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, University of Turin, Turin, Italy;
3 Molecular Biotechnology Center, University of Turin, Turin, Italy


FULL TEXT  


Genomic analyses have revolutionized research on human health and infectious diseases. These techniques led to the discovery of new virulence determinants in different pathogens in turn providing new potential therapeutic targets. Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for various diseases. H. pylori infects around a half of the world population and its infection entails an inflammatory response that may promote the formation of peptic ulcer and, in some cases, may led to the development of gastric cancer. However, not all infected subjects develop lesions more severe than gastritis due to the different nature of the disease that depends not only on the bacterium, but also on host characteristics such as genetic predisposition and environmental factors. Analysis of H. pylori genome has revealed a coevolution between the pathogen itself and the host, and any perturbation of this equilibrium disrupts the hostpathogen interaction promoting the oncogenic effects. In this review, we have summarized new molecular insights concerning the pivotal steps of H. pylori infection focusing on colonization, survival and antibiotic resistance, with the aim of translating this knowledge to the clinical setting for the development of new therapeutic strategies.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail