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REVIEWS  MicroRNAs: from basic research to therapeutic applications


Minerva Biotecnologica 2014 Giugno;26(2):93-102

lingua: Inglese

SPR-based identification of microRNAs

Breveglieri G. 1, 2, Bianchi N. 1, Finotti A. 1, Gambari R. 1

1 Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy;
2 Biotechnology Center, University of Ferrara, Ferrara, Italy


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MicroRNAs (miRNAs) are small non-coding endogenous RNAs acting as post-transcriptional regulators of gene expression in eukaryotes, that play important roles in homeostatic cell processes such as development, proliferation and apoptosis. Recently, the deregulation of miRNA levels has been linked to the pathogenesis of several human diseases, including cancer initiation and progression, making them useful as prognostic and diagnostic biomarkers. Among the novel detection strategies required to identify and quantify specific miRNAs in biological samples, ultrasensitive and specific methods based on Surface Plasmon Resonance are under development in order to overcome some pitfalls of conventional miRNA diagnostic techniques.

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