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Minerva Biotecnologica 2007 June;19(2):71-4

Copyright © 2007 EDIZIONI MINERVA MEDICA

lingua: Inglese

Antibody-antigen interactions in dielectrophoresis buffers for cell manipulation on dielectrophoresis-based Lab-on-a-chip devices

Borgatti M. 1, Rizzo R. 2, Mancini I. 1, Fabbri E. 1, Baricordi O. 2, Gambari R. 1, 3

1 Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassemia Biotechnology Center, University of Ferrara, Ferrara, Italy 2 Section of Human Genetic, Department of Experimental and Diagnostic Medicine University of Ferrara, Ferrara, Italy 3 ER-GenTech, Department of Biochemistry and Molecular Biology University of Ferrara, Ferrara, Italy


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In this review we present data supporting the feasibility to perform experiments based on dielectrophoresis (DEP) and on molecular interactions between monoclonal antibodies and membrane proteins. This allows propose DEP-based Lab-on-a-chip platforms for several biotechnological applications depending on the interactions between monoclonal antibodies and target cells, including immunophenotype characterization, isolation of rare cells, drug targeting.

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