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Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Online ISSN 1827-160X
NEW TRENDS IN BIOENCAPSULATION - Part 1
El Mafadi S., Picot A., Poncelet D.
UMR GEPEA, ENITIAA, Nantes, France
The Wurster process is a coating technique that is well suited to uniformly coat or encapsulate individual particulate materials. However, its use for coating sensitive bioactive compounds is often limited because of the potential risks of degradation during operations.
In order to avoid a loss of integrity of such material during the process, we proposed some modifications of the equipment. The standard and modified systems were compared using probiotic microorganisms as model for sensitive material.
The results obtained for the pressure drop measurements at various air flow rates are rapresented by a 4 distinct states of fluidization for the conventional equipment and only 3 states (S1, S2 and S3) for the modified one.
Our results demonstrated that the modifications carried out led to more gentle operating conditions, resulting in an enhanced cell survival during the coating process.