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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOMINERVA BIOTECNOLOGICA

Rivista di Biologia Molecolare e Biotecnologie

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Periodicità: Trimestrale

ISSN 1120-4826

Online ISSN 1827-160X

 

Minerva Biotecnologica 2002 Giugno;14(2):165-9

7th INTERNATIONAL CONFERENCE ON TRANSGLUTAMINASES AND PROTEIN CROSSLINKING REACTIONS
Ferrara (Italy), September 14-17, 2002 

 REVIEWS

Transglutaminases in skin biology

Ahvazi B., Boeshans K., Jang S.-I., Kalinin A. E., Steinert P. M.

Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

Dur­ing ­their ter­mi­nal dif­fe­ren­ti­a­tion pro­grams, all strat­i­fied squa­mous epi­the­lia assem­ble an elab­orate insol­u­ble bar­ri­er struc­ture, gener­i­cal­ly ­termed the corn­i­fied ­cell enve­lope (CE), on the ­inside of ­their plas­ma mem­brane at the ­cell periph­ery. ­This struc­ture pro­vides a ­vital phys­i­cal and/or bio­me­chan­i­cal bar­ri­er for the ­mature tis­sue and organ­ism. The CE is com­posed of sev­er­al ­defined struc­tu­ral pro­teins ­that ­become ­cross-­linked togeth­er by the ­action of one or ­more trans­glu­tam­i­nase (­TGase) ­enzymes. ­Recent stud­ies on the com­plex­ity of the fam­i­ly of ­TGase ­enzymes and the ­initial ­draft of the ­human ­genome ­have ­revealed the pres­ence of ­nine ­TGase-­like ­genes. Of ­these, six ­active ­genes/­enzymes are now ­known to be ­expressed in epi­the­lial ­cells. ­This bewil­der­ing com­plex­ity strong­ly ­implies ­that the prop­er assem­bly of the CE is ­indeed ­vital for sur­vi­val.

lingua: Inglese


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