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Minerva Biotecnologica 2000 Dicembre;12(4):293-300

lingua: Inglese

Hydroxy pro­pyl meth­yl cel­lu­lose phtha­late (­HPMCP) micro­par­ti­cles for enter­ic deliv­ery of glu­co­sin­o­late ­derived prod­ucts ­from Cruciferous veg­e­ta­ble

Cortesi R. 1, Esposito E. 1, Cantelli D. 1, Nastruzzi C. 2

1 Dipartimento di Scienze Farmaceutiche, Università ­degli Studi di Ferrara, Ferrara, Italy;
2 Dipartimento di Chimica e Tecnologia del Farmaco, Università ­degli Studi di Perugia, Perugia, Italy


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This ­paper ­describes the pro­duc­tion and char­ac­ter­iza­tion of bio­de­grad­able micro­par­ti­cles con­tain­ing glu­co­sin­o­late hydrol­y­sis prod­ucts, ­designed for enter­ic deliv­ery. Hydroxy pro­pyl meth­yl cel­lu­lose phtha­late (HPMCP) micro­par­ti­cles ­were pro­duced by a dou­ble emul­sion pro­cess ­using as exter­nal ­phase 0.1% poly­vi­nyl alco­hol solu­tion at pH 3.5. Microparticle mor­phol­o­gy was char­ac­ter­ized by opti­cal and elec­tron micros­co­py. The ­release kinet­ics of the ­drugs ­from micro­spheres was deter­mined ­using a dial­y­sis meth­od. The dou­ble emul­sion meth­od ­here ­described ­allows the pro­duc­tion of micro­par­ti­cles ­with ­high encap­su­la­tion effi­cien­cy and appro­pri­ate dimen­sion­al and mor­pho­log­i­cal char­ac­ter­is­tics for ­oral admin­is­tra­tion. Release pro­file ­data indi­cate ­that the encap­su­lat­ed ­drug is ­released ­from micro­par­ti­cles ­with a ­rate ade­quate to a sus­tained enter­ic deliv­ery.

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