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Minerva Biotecnologica 2000 December;12(4):265-9

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Enzyme encapsulation for biocatalysis in organic solvents. New approaches to the stereoselective synthesis of pharmaceutical compounds

Ansorge-Schumacher M. B., Doumèche B., Metrangelo D., Hartmeier W.

Department of Biotechnology, Technical University of Aachen (RWTH), Aachen, Germany


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The encap­su­la­tion of bio­cat­a­lysts in nat­u­ral or syn­thet­ic hydro­gels is a ver­sa­tile ­tool to ­apply ­enzymes to syn­the­sis in organ­ic sol­vents. ­Thus, ­even sen­sible or cofac­tor-depen­dent cat­a­lysts ­like alco­hol dehy­dro­ge­nas­es are pro­tect­ed ­from det­ri­men­tal envi­ron­men­tal ­effects and ­might be ­employed to pro­duce sin­gle-enan­tiom­er ­drugs, insol­u­ble in aque­ous solu­tions.

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