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Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Online ISSN 1827-160X
Department of Biomedical Sciences, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy
Apoptosis is a phenomenon of crucial importance in all multicellular, living organisms: it is involved in several physiological and pathological phenomena which incluse embryogenesis, differentiation, development of the immune system, as well as control of cell growth, cancerogenesis, viral production. The assumption that apoptosis is an active process led to study mitochondria, the main intracellular source of energy, which is produced in form of ATP. It is reasonable to hypothesize that, at least in early apoptotic phases, cells have to maintain a good driving force for ATP synthesis, and, consequently, a high mitochondrial membrane potential (∆Ψ), that becomes a reliable mirror of the capacity to synthesize ATP and, in general, of mitochondrial membrane functionality. In this article, the use of different fluorescent probes for the analysis of ∆Ψ is discussed paying a particular attention for JC-1, that is considered the golden standard for this type of measure.