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Rivista di Biologia Molecolare e Biotecnologie


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Minerva Biotecnologica 1999 December;11(4):311-7

Copyright © 1999 EDIZIONI MINERVA MEDICA

lingua: Inglese

Adaptative immunotherapy of advanced solid tumors

Semino C. 1, Ferlazzo G. 1, Ratto G. B. 2, Melioli G. 1

1 Laboratorio di Immunoterapia Cellulare, Istituto Nazionale per la Ricerca sul Cancro; 2 Cattedra di Chirurgia Toracica, Università degli Studi di Genova, Genova


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Adoptive immunotherapy (AI) of cancer, based upon injection of in vitro manipulated autologous lymphocytes is still in an experimental phase. Based on strong experimental and pre-clinical rationale, our group started different clinical trials of AI in early 1990, and a number of patients with solid tumors (melanoma, kidney carcinoma, non-small-cell lung cancer, mesothelioma, neoplastic pleural effusion, and liver cancer) were treated with either locoregional or systemic adoptive immunotherapy using both LAK and TIL cells in combination with s.c. rIL-2. The surgery/AI combination resulted in good clinical results, characterized by enhanced survival and long lasting disease free periods in a significant number of patients. Nevertheless, at present, new preclinical evidences and strategies are needed to enhance the efficacy of the adoptive immunotherapy approach of solid tumor treatment.

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