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Rivista di Biologia Molecolare e Biotecnologie
Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Minerva Biotecnologica 1999 December;11(4):261-70
Presentation of tumor antigens. The role of dendritic cells
Paglia P., Colombo M. P.
mmunotherapy and Gene Therapy Unit, Istituto Nazionale Tumori, Milano, Italy
Human tumors express a number of protein antigens that can be recognized by T cells, thus providing potential targets for cancer immunotherapy. Dendritic cells are rare leukocytes that are uniquely potent in their ability to present antigens to T cells, and this property has prompted their recent application to therapeutic cancer vaccines. Isolated dendritic cells loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals. In pilot clinical trials of dendritic cells vaccination for patients with non-Hodgkints lymphoma and melanoma, induction of anti-tumor immune responses and tumor regressions have been observed. Additional trials of dendritic cells vaccination for a variety of human cancers are under- way, and methods for targeting tumor antigens to dendritic cells in vivo are also being explored. Exploitation of the antigen-presenting properties of dendritic cells thus offers promise for the development of effective cancer immunotherapies.