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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOMINERVA BIOTECNOLOGICA

Rivista di Biologia Molecolare e Biotecnologie

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Periodicità: Trimestrale

ISSN 1120-4826

Online ISSN 1827-160X

 

Minerva Biotecnologica 1999 Giugno;11(2):101-6

FLOW CYTOMETRY IN IMMUNOLOGY AND HEMATOLOGY 

Detec­tion of T-cells ­expressing inhib­i­tory NK-cell recep­tors ­within non-­small-­cell ­lung ­cancer ­tumor infil­trating lym­pho­cytes. A ­flow cyto­metric anal­ysis

Semino C., Melioli G.

Unità di Immu­not­e­rapia Cel­lu­lare, Isti­tuto Nazi­o­nale per la ­Ricerca sul ­Cancro, ­Genova, ­Italy

Nat­ural ­killer (NK) ­cell inhib­i­tory recep­tors (­INKR) ­have ­been ­described to be detect­able ­both on NK ­cells and on a ­subset of ­normal ­human T-lym­pho­cytes. To eval­uate the fre­quency of ­tumor infil­trating lym­pho­cytes ­expressing ­INKR in a ­group of sam­ples ­derived ­from ­human non ­small ­cell ­lung ­cancer, a cytof­lu­or­i­metric anal­ysis was per­formed. ­Using ­this ­approach, it has ­been ­observed ­that T-­cells ­expressing ­INKR are oli­goc­lonal and ­express a ­memory phe­no­type on ­their sur­face. The fre­quency of ­INKR in TIL sig­nif­i­cantly dif­fers ­from ­that ­observed in autol­o­gous periph­eral ­blood sam­ples. The pres­ence of ­INKR pos­i­tive ­cells ­could sig­nif­i­cantly inter­fere ­with adop­tive immu­no­therapy pro­to­cols for the con­trol of non ­small ­cell ­lung ­cancer ­spread.

lingua: Inglese


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