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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Periodicità: Mensile

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2016 Nov 11

Minimum local anaesthetic volumes for a selective saphenous nerve block: a dose-finding study

Werner TEN HOOPE 1, Markus W. HOLLMANN 1, Arthur ATCHABAHIAN 2, Marcel RIGAUD 3, Gino M. KERKHOFFS 4, 5, Philipp LIRK 1, Holger M. BAUMANN 1

1 Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 2 Department of Anaesthesiology, New York University School of Medicine, New York, NY, USA; 3 Department of Anaesthesiology and Intensive Care Medicine, Medical University, Graz, Austria; 4 Department of Orthopedic Surgery, Academic Center for Evidence Based Sports Medicine (ACES), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 5 Amsterdam Collaboration for Health and Science in Sports (ACHSS), Amsterdam, The Netherlands

BACKGROUND: Saphenous nerve block contributes to analgesia after knee and lower leg surgery. However, literature reports a wide range of volumes of local anaesthetic being used for this block.
METHODS: A non-randomized controlled trial in a single university hospital in March 2015. Eighteen healthy volunteers (ASA 1 status, aged 27-43 years; male/female ratio 11 vs. 7) were needed to determine the minimum local anaesthetic volume (MLAV) of mepivacaine 2% using the Dixon up-and-down method to achieve a selective ultrasound-guided saphenous nerve block. The primary endpoint MLAV (ED50 and ED95) for an ultrasound-guided saphenous nerve block were determined. The secondary endpoints were the position of the saphenous nerve, block onset and duration of action, cutaneous spread of the block, and the occurrence of femoral nerve motor block.
RESULTS: The measured MLAV dose that was effective in 50% of cases (ED50) for a complete saphenous nerve block was 1.5 mL; the calculated MLAV dose for 95% of cases (ED95) was 1.9 mL. The saphenous nerve was encountered in almost all cases on the anterior / anteromedial aspect of the femoral artery. We found no correlation between local anaesthetic volume and the onset or duration of the block. Cutaneous spread of the nerve block was observed on the anteromedial aspect of the lower leg, with considerable individual variation between individuals in the study. No femoral motor block was observed.
CONCLUSIONS: For a selective ultrasound-guided saphenous nerve block, the ED95 MLAV of mepivacaine 2% is 1.9 mL.

lingua: Inglese


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