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Online ISSN 1827-1596
Juan P. CATA 1, 2, 5, Dario BUGADA 3, 4, 5, Jose DE ANDRÉS 5, 6
1 Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, TX, USA; 2 Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA; 3 Department of Surgical Sciences, University of Parma, Parma, Italy; 4 Department of Anesthesia, ICU and Pain Therapy, Parma University Hospital, Parma, Italy; 5 SIMPAR Group, Parma, Italy; 6 Anesthesia, Critical Care and Multidisciplinary Pain Management Department, Valencia University General Hospital, Valencia, Spain
Opioids are the most frequently administered analgesics in the perioperative period. The analgesic potency of opioids is without question. While the opioid- free or opioid-less perioperative care concept is not a reality in most surgical centers of the United States and other developed countries, there is a significant number of healthcare problems (i.e. adverse events, opioid-induced hyperalgesia and opioid diversion) related to the indiscriminate use of opioids that warrants the implementation of multimodal analgesia strategies. Although it has been suggested an association between the use of opioids and cancer progression, there is a need of well-designed studies to confirm that association.