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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Periodicità: Mensile

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2016 Sep 13

The optimal time between clinical brain death diagnosis and confirmation using CT angiography : a retrospective study

Lionel KERHUEL 1, Mohamed SRAIRI 1, Gilles GEORGET 1, Fabrice BONNEVILLE 2, Ségolène MROZEK 1, Nicolas MAYEUR 1, Laurent LONJARET 1, Sandrine SACRISTA 1, Nathalie HERMANT 1, Fouad MARHAR 1, François GAUSSIAT 1, Timothée ABAZIOU 1, Diane OSINSKI 1, Benjamin Le GAILLARD 1, Rémi MENUT 1, Claire LARCHER 1, Olivier FOURCADE 1, Thomas GEERAERTS 1

1 Department of Anaesthesia and Intensive Care, University Hospital of Toulouse, University Toulouse 3 Paul Sabatier, Toulouse, France; 2 Department of Neuroradiology, University Hospital of Toulouse, University Toulouse 3 Paul Sabatier, Toulouse, France

BACKGROUND: In several countries, a computed tomography angiography (CTA) is used to confirm brain death (BD). A six-hour interval is recommended between clinical diagnosis and CTA acquisition despite the lack of strong evidence to support this interval. The aim of this study was to determine the optimal timing for CTA in the confirmation of BD.
METHODS: This retrospective observational study enrolled all adult patients admitted between january 2009 and december 2013 to the intensive care units of a French university hospital with clinically diagnosed BD and at least one CTA performed as a confirmatory test. The CTAs were identified as conclusive (e.g. yielding confirmation of BD) or inconclusive (e.g. showing persistent brain circulation).
RESULTS: One hundred and four patients (sex ratio M/F 1.8; age 55 years [41-64]) underwent 117 CTAs. CTAs confirmed cerebral circulatory arrest in 94 cases yielding a sensitivity of 80%. Inconclusive CTAs were performed earlier than conclusive ones (2 hours [1–3] vs. 4 hours [2–9], p = 0.03) and were associated with decompressive craniectomy (5 cases (23%) vs. 6 cases (7%), p = 0.05) and the failure to complete full neurological examination (5 cases (23%) vs. 4 cases (5%), p = 0.02). Six hours after BD clinical diagnosis, the proportion of conclusive CTA was only 51%, with progressive increase overtime with more than 80% of conclusive CTA after 12 hours.
CONCLUSIONS: A 12-hour interval might be appropriate in order to limit the risk of inconclusive CTAs.

lingua: Inglese


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