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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Anestesiologica 2016 Aug 30

lingua: Inglese

Continuous epidural versus wound infusion plus single morphine bolus as postoperative analgesia in open abdominal aortic aneurysm repair: a randomized non-inferiority trial

Lorenzo BALL 1, Giulia PELLERANO 1, Laura CORSI 2, Nadia GIUDICI 2, Anna PELLEGRINO 2, Daniela CANNATA 2, Gregorio SANTORI 1, Domenico PALOMBO 1, Paolo PELOSI 1, Angelo GRATAROLA 2

1 Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, IRCCS AOU San Martino-IST, Università degli Studi di Genova, Genova, Italy; 2 Dipartimento di Anestesia e Rianimazione, IRCCS AOU San Martino-IST, Genova, Italy


BACKGROUND: We compared a bundle of interventions including wound infiltration and continuous infusion with local anaesthetics plus a single morphine bolus (CWI-M) with continuous epidural infusion (CEI) as postoperative analgesia.
METHODS: Fifty-one adults undergoing open abdominal aortic aneurysm repair were randomised in this non-inferiority open-label trial. In the CEI group, patients received thoracic epidural levobupivacaine 0.12% plus sufentanil 0.4 g·ml-1 infusion for 48h. In the CWI-M group, the wound was infiltrated with 10 ml levobupivacaine 0.5%, patients received a morphine bolus before the end of anaesthesia and levobupivacaine 0.25% infusion through two multi-holed pre-peritoneal catheters for 48h. Systemic morphine was administered as rescue in both groups. The primary endpoint was the mean NRS in the first 48h after surgery.
RESULTS: Mean NRS was 1.7 (95% CI: from 1.2 to 2.2) in the CEI and 2.2 (95% CI: from 1.7 to 2.7) in the CWI-M group, the 90% CI of difference was from -0.1 to 1.1, not including the non- inferiority margin of 1.3. The cumulative rescue morphine dose per patient was higher in CWI-M than in CEI group (3.7 ± 4.4 mg vs. 0.8 ± 2.4, p = 0.006); moreover, NRS at arousal was higher in CWI-M (p = 0.003). No differences were observed in postoperative haemodynamic parameters, recovery-related outcomes, length of stay nor complications.
CONCLUSIONS: CWI-M was comparable to CEI in in postoperative pain control, but it was associated with higher need of rescue systemic opiates and with a worse early pain control.

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