Home > Riviste > Minerva Anestesiologica > Fascicoli precedenti > Minerva Anestesiologica 2017 June;83(6) > Minerva Anestesiologica 2017 June;83(6):553-62

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

MINERVA ANESTESIOLOGICA

Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,623


eTOC

 

ORIGINAL ARTICLE  


Minerva Anestesiologica 2017 June;83(6):553-62

DOI: 10.23736/S0375-9393.17.11068-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Aggressive versus conservative antibiotic use to prevent and treat ventilator-associated pneumonia in patients with severe traumatic brain injury: comparison of two case series

Arturo CHIEREGATO 1, Paolo MALACARNE 2 , Francesco COCCIOLO 3, Maurizio RAVALDINI 3, Emanuele RUSSO 3, Bruno VIAGGI 4, Michele GIARDINO 5, Carlotta ROSSI 5, Bruno SIMINI 6, Guido BERTOLINI 5

1 Unit of Neuororesuscitation, Department of Anesthesia, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; 2 Unit of Anesthesia and Resuscitation, AOU Pisa, Pisa, Italy; 3 Unit of Anesthesia and Resuscitation, AUSL Romagna, Cesena, Forlì Cesena, Italy; 4 Unit of Neuroanesthesia and Intensive Therapy, AOU Careggi, Florence, Italy; 5 GiViTI Coordinating Center, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò, Ranica, Bergamo, Italy; 6 Lucca Provincial Hospital, ASL Lucca, Lucca, Italy


PDF  SUPPLEMENTARY MATERIAL  


BACKGROUND: In patients with traumatic brain injury (TBI), ventilator-associated pneumonia (VAP) is considered a dangerous complication, prompting early aggressive antibiotic treatment and prophylaxis. While this approach increases the selection of multidrug-resistant bacteria (MDR), its clinical benefit has not been demonstrated.
METHODS: One-year incidence of VAP in severe TBI patients (ICU stay >48 hours, with either Glasgow Coma Scale ≤8 or receiving intracranial pressure monitoring, or having undergone emergency surgery) and the prevalence of MDR among those who eventually developed it, were compared in two Italian intensive care units (ICUs) adopting different antibiotic approaches. Antibiotic use was guideline-driven and aggressive in the Pisa-based unit (165 eligible patients), and very conservative and coupled with non-pharmacological prevention measures in Cesena (262 patients). Data were also compared with those of 208 Italian ICUs participating in the same infection surveillance program.
RESULTS: Patient case mix and general care were similar in the two units. Overall antibiotic pressure was higher in Pisa (58.9% vs. 26.1% of beds occupied by patients receiving antibiotics, P<0.0001), as was antibiotic prophylaxis in eligible patients (87.3% vs. 7.6%, P<0.0001; Italian ICUs, 69.2%) and empirical therapy in those who developed VAP (60.8% vs. 25.2%, P<0.0001; Italian ICUs, 51.6%). The incidence rate of VAP did not significantly differ (39.8 per 1000 days of mechanical ventilation in Pisa, 49.3 in Cesena, P=0.16), although it occurred earlier in Cesena (23.0% early VAP in Pisa vs. 61.2% in Cesena, P<0.0001). Mortality was higher in Pisa but Cesena transferred more patients to other hospitals, precluding comparison of the two rates. The prevalence of MDR was higher in Pisa (38.2% vs. 9.9%, P<0.0001; Italian ICUs, 30.2%).
CONCLUSIONS: Although not conclusive, these results call into question the prevalent aggressive use of antibiotics in TBI patients and urge the scientific community to produce better evidence for clinical recommendations.


KEY WORDS: Antibiotic prophylaxis - Brain injuries - Drug resistance, bacterial - Intensive care units - Pneumonia, ventilator-associated

inizio pagina

Publication History

Issue published online: June 7, 2017
Article first published online: March 8, 2017
Manuscript accepted: March 7, 2017
Manuscript revised: March 3, 2017
Manuscript received: November 22, 2015

Per citare questo articolo

Chieregato A, Malacarne P, Cocciolo F, Ravaldini M, Russo E, Viaggi B, et al. Aggressive versus conservative antibiotic use to prevent and treat ventilator-associated pneumonia in patients with severe traumatic brain injury: comparison of two case series. Minerva Anestesiol 2017;83:553-62. DOI: 10.23736/S0375-9393.17.11068-0

Corresponding author e-mail

pmalacarne@hotmail.com