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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva
Minerva Anestesiologica 2016 November;82(11):1170-9
Propofol versus midazolam for premedication: a placebo‑controlled, randomized double‑blinded study
Ofelia L. ELVIR LAZO 1, Paul F. WHITE 1, 2, 3, Jun TANG 1, Roya YUMUL 1, 4, Xuezhao CAO 1, 5, Firuz YUMUL 1, Jonathan HAUSMAN 1, Antonio HERNANDEZ CONTE 1, Kapil K. ANAND 1, Emad G. HEMAYA 1, Xiao ZHANG 1, Ronald H. WENDER 1 ✉
1 Department of Anesthesiology, Cedars‑Sinai Medical Center, Los Angeles, CA, USA; 2 White Mountain Institute, The Sea Ranch, CA, USA; 3 Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy; 4 David Geffen School of Medicine‑UCLA, Los Angeles, CA, USA; 5 First Affiliated Hospital of China Medical University, Shenyang, China
BACKGROUND: It has been previously reported that subhypnotic doses of propofol could offer an advantage over midazolam for premedication. This study was designed to test the hypothesis that a 20 mg IV dose of propofol would be more effective than a standard 2 mg IV dose of midazolam for reducing acute anxiety prior to induction of anesthesia.
METHODS: One hundred twenty outpatients scheduled to undergo orthopedic surgery were randomly assigned to one of three study groups: control (saline); propofol (20 mg); or midazolam (2 mg). Immediately before administering the study medication, each patient evaluated their level of acute anxiety and sedation on 11‑point verbal rating scales (VRSs) 0=none- 10=highest, and they were also shown a picture. Upon arrival in the OR ~5 min after administering the study medication, anxiety and sedation levels were reassessed and a second picture was shown. At discharge from the recovery area, anxiety and sedation levels and their ability to recall the two pictures were reassessed.
RESULTS: Compared to the saline group, both propofol and midazolam produced significant increases in the patient’s level of sedation upon entering the OR (+2.5±2.4 vs. +4.6±2.5 and +5.2±2.3, respectively [p<0.001]). Propofol was effective as midazolam compared to saline in reducing the patient’s level of preinduction anxiety (from 3.2±2.2 to1.8±1.8 vs. 3.1±2.2 to 2.3±2.1 and 2.7±1.8 to 2.8±2.1, respectively). Propofol produced more pain on injection and midazolam significantly reduced recall of the second picture.
CONCLUSIONS: When administered ~5 min prior to entering the OR, propofol, 20mg IV, was as effective as midazolam 2mg IV in reducing anxiety.