Home > Riviste > Minerva Anestesiologica > Fascicoli precedenti > Minerva Anestesiologica 2012 September;78(9) > Minerva Anestesiologica 2012 September;78(9):1054-66

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

MINERVA ANESTESIOLOGICA

Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036


eTOC

 

REVIEWS  


Minerva Anestesiologica 2012 September;78(9):1054-66

lingua: Inglese

How to prevent ventilator-induced lung injury?

De Prost N. 1, Dreyfuss D. 2, 3, 4

1 Assistance Publique, Hôpitaux de Paris, Hôpital Henri Mondor, Service de Réanimation Médicale, Créteil, France;
2 Université Paris-Diderot and PRES Sorbonne Paris Cité, Site Xavier Bichat, Paris, France;
3 Assistance Publique, Hôpitaux de Paris, Hôpital Louis Mourier, Service de Réanimation Médicale, Colombes, France;
4 INSERM U722, Paris, France


FULL TEXT  


The experimental evidence that ventilator could injure lungs through the application of excessive end-inspiratory volumes and transpulmonary pressures has led to major changes in the clinical management of patients suffering from the acute respiratory distress syndrome (ARDS). The prevention of ventilator-induced lung injury has become one of the main goals of current ventilator strategies for patients with ARDS as well as for patients with normal lungs that require mechanical ventilation. Tidal volume reduction allowed for a reduction in mortality that confirmed the clinical relevance of ventilator-induced lung injury. In contrast, strategies for setting positive end-expiratory pressure (PEEP) have been proposed but the optimal PEEP level remains unsettled. Considerable efforts have been made within the last decades to try to develop new ventilator strategies as well as pharmacological and mechanical measures in order to prevent VILI and further improve the outcome of ARDS patients. This review will strive to describe seminal experimental and clinical studies that aimed at preventing the development of VILI.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

didier.dreyfuss@lmr.aphp.fr