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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva
Minerva Anestesiologica 2008 Giugno;74(6):233-43
Sufentanil-propofol vs remifentanil-propofol during total intravenous anesthesia for neurosurgery. A multicentre study
Martorano P. P. 1, Aloj F. 2, Baietta S. 3, Fiorelli A. 4, Munari M. 5, Paccagnella F. 6, Rosa G. 7, Scafuro M. 8, Zei E. 9, Falzetti G. 1, Pelaia P. 1
1 Institute of Medical and Surgical Emergencies, Polytechnic University of Marche, Ancona, Italy;
2 I.R.C.C.S. “Neuromed” Anesthesia and Intensive Care Department, Isernia (CB), Italy;
3 Anesthesiology and Intensive Care, University and City Hospital, Verona, Italy;
4 “S. Giovanni-Addolorata” Hospital, 3rd Department of Anesthesia, Rome, Italy;
5 Farmacology and Anesthesiology Institute, University of Padua, Padua, Italy;
6 Department of Anesthesiology, “Cà Foncello” Regional Hospital, Treviso, Italy;
7 Institute of Anesthesia and Intensive Care, University of Rome “La Sapienza”, Rome, Italy;
8 Anesthesiology and Neurologic Science Department, Second University of Naples, Naples, Italy;
9 Neuro-Anesthesia Unit, University of Siena, Siena, Italy
Background. In a randomised, prospective multi-centre study, we compared the intraoperative and postoperative effects of two opioids: sufentanil and remifentanil, in combination with propofol in two groups of patients undergoing neurosurgery.
Methods. After Local Ethics Committee approval and informed consent obtaining, 69 patients undergoing neurosurgery for supratentorial tumours, between 18 and 75 years of age were randomised to receive either sufentanil or remifentanil in combination with propofol. Intraoperative and postoperative haemodynamic variables, recovery times (time to eye opening and to extubation), the incidence of postoperative respiratory depression, pain, nausea and vomiting were also evaluated. The Short Orientation-Memory-Concentration Test was used to evaluate cognitive function at 15, 45 and 180 min after emergence from anesthesia.
Results. There were no significant differences between the groups in the duration of surgery and anesthesia, mean arterial pressure, heart rate, time to eye opening or extubation. The incidence of vomiting, respiratory depression and shivering was similar in both groups. Postoperative pain requiring supplemental analgesics was significantly lower in the sufentanil group (P<0.05). Although there were no significant differences between the groups in postoperative behavioural examinations by Rancho Los Amigos Test, patients anesthetised with sufentanil had significantly better Short Orientation-Memory-Concentration Test values at 15 and 180 min postoperatively (P<0.05).
Conclusion. We conclude that remifentanil and sufentanil are suitable adjunct to propofol for total intravenous anesthesia (TIVA). Patients receiving sufentanil have reduced analgesic requirements and better cognitive function postoperatively than those who received remifentanil.