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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2016 Jun 17

lingua: Inglese

Orthostatic loading-induced transient venous refluxes (day orthostatic loading test) and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein


Department of Surgical Diseases, Omsk State Medical University, Omsk, Russia


BACKGROUND: Orthostatic loading can induce transient venous reflux (TVR). Among patients with telangiectasia and reticular varices, we determined the proportion that developed TVR after a day of orthostatic loading (DOL test), and investigated the remedial effects of micronized purified flavonoid fraction (MPFF).
METHODS: All 96 patients enrolled in this study had telangiectasia and reticular varices. Patients underwent duplex scanning (DS) in the morningand evening, and vein diameters were measured. Patients with detectable evening TVR were treateddaily with MPFF (Daflon1000 mg) for 90 days, andthen reassessed. Patient quality of life (QOL) wasevaluated using the Chronic Venous Insufficiency Questionnaire (CIVIQ-2).
RESULTS: At baseline, patients had telangiectasia (45.8%), reticular varices (13.5%), orboth (40.7%). TVR was absent in all patients in the morning but present in over half (55.2%) in the evening. All TVR patients complained of leg heaviness versus 16.3% of non-TVR patients. The great saphenous vein (GSV) diameters of patients with TVR were significantly greaterthan those without (Р<0.0001). After MPFF treatment, TVR was eliminated in mostpatients (92.5%). The GSV diameter intreated patients was significantly reduced from baseline (5.69 mm–5.14 mm; Р=0.000001). The majority of patients (88.6%) no longer experienced leg heaviness, with 11.4% having reduced symptoms. QOL improved.
CONCLUSIONS: Over half of patients with telangiectasia and reticular varices experience TVR.TVRs can be exposedusing the DOL test, which has noimpact upon daily life. Daily MPFF(Daflon® 1000 mg) treatment over90 days eliminated TVR, resolved venous symptoms, and improved QOL.

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