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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2017 August;36(4):354-61

DOI: 10.23736/S0392-9590.16.03798-6

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Deterioration of endothelial function of micro- and macrocirculation in patients with diabetes type 1 and 2

Hana BESIC, Luka JERAJ, Ana SPIRKOSKA, Mateja K. JEZOVNIK, Pavel POREDOŠ

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia


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BACKGROUND: Vascular complications are an important cause of morbidity in patients with diabetes mellitus (DM). Endothelial dysfunction is an early marker of atherosclerosis and has already been shown in macrocirculation of diabetic patients; however, data on endothelial function of microcirculation is scarce. Our aim was to evaluate endothelial function in macro- and microcirculation and their interrelationship in patients with type 1 and 2 DM.
METHODS: The study included 30 patients with type 1 DM, 30 patients with type 2 DM and 25 healthy controls. The endothelial function of large arteries was studied measuring flow-mediated dilation (FMD). Peripheral arterial tonometry was used for investigation of the endothelial function of microcirculation, measuring Reactive Hyperemia Index (RHI) and Augmentation Index (AI).
RESULTS: In comparison to controls, both DM groups had decreased FMD: type 1 (4.0±5.0% vs. 10.0±7.8%, P=0.005) and type 2 (5.0±0.6% vs. 10.0±7.8%, P=0.007). However, only type 2 DM group had a lower RHI (1.71±0.44 vs. 2.05±0.54, P=0.017) in comparison to controls.
CONCLUSIONS: Patients with type 1 and 2 DM had deteriorated functional capability of macrocirculation. However, endothelial dysfunction of microcirculation was present only in type 2 DM patients. Type 2 DM patients were also at higher risk for atherosclerosis because of the more frequent presence of risk factors.


KEY WORDS: Diabetes mellitus, type 1 - Diabetes mellitus, type 2 - Microcirculation

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Publication History

Issue published online: June 8, 2017
Article first published online: December 20, 2016
Manuscript accepted: December 5, 2016
Manuscript received: November 28, 2016

Per citare questo articolo

Besic H, Jeraj L, Spirkoska A, Jezovnik MK, Poredoš P. Deterioration of endothelial function of micro- and macrocirculation in patients with diabetes type 1 and 2. Int Angiol 2017;36:354-61. DOI: 10.23736/S0392-9590.16.03798-6

Corresponding author e-mail

pavel.poredos@kclj.si