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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2016 December;35(6):546-51

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Association of RBP4 levels with increased arterial stiffness in adolescents with family history of type 2 diabetes

Ping LI 1, Yamin LU 2, Guangyao SONG 3, Boqing MA 3, Jing LIU 3, Jinhu CHEN 3, Chao LIU 3

1 Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; 2 Department of Nuclear Medicine, Hebei General Hospital, Shijiazhuang, China; 3 Department of Endocrinology, Institute of Endocrinology and Metabolism, Hebei General Hospital, Shijiazhuang, China


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BACKGROUND: The aim of this study was to explore the impact of family history of type 2 diabetes (FH2D) on arterial stiffness in young people and its relationship to adipocytokines.
METHODS: This case-control study included 52 adolescents (male/female 28/24) with FH2D (FH2D+) and 40 adolescents (male/female 21/19) without FH2D (FH2D-). Anthropometric measurements, including height, weight, waist circumference (WC), and blood pressure, were obtained. Blood samples were collected, fasting plasma glucose (FPG), serum lipids, Retinol Binding Protein 4 (RBP4), C reactive protein (CRP), adiponectin and visfatin were examined. Brachial-ankle pulse wave velocity (baPWV) was used to evaluate arterial stiffness. Visceral fat area (VFA) was measured by computerized tomography.
RESULTS: Compared with FH2D- group, FH2D+ group had a significantly higher oral glucose tolerance test (OGTT) 2-hour insulin, RBP4 and baPWV levels, a lower adiponectin and glucose infusing rate (GIR) (P<0.05). BaPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), 2-hour (OGTT) insulin, RBP4, and VFA, and negatively correlated with GIR in FH2D+ group. After multivariate analysis, age, SBP, RBP4 and VFA maintained an independent association with baPWV in FH2D+ group (P<0.05), while only age, SBP, and VFA were independent predictors of baPWV in FH2D- group (P<0.05).
CONCLUSIONS: These findings led to the conclusion that RBP4 level was associated with increased arterial stiffness in young subjects with family history of type 2 diabetes.

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Per citare questo articolo

Li P, Lu Y, Song G, Ma B, Liu J, Chen J, et al. Association of RBP4 levels with increased arterial stiffness in adolescents with family history of type 2 diabetes. Int Angiol 2016 December;35(6):546-51. 

Corresponding author e-mail

sguangyao3@163.com