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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Jerzy CHUDEK 1, Jacek MIKOSIŃSKI 2, Andrzej KOBIELSKI 3, Artur HERING 4, Tomasz ALEKSIEJEW-KLESZCZYŃSKI 5, Jacek UMIŃSKI 6, Tomasz ZUBILEWICZ 7, Wojciech KOBUSIEWICZ 7, Marek IŁŻECKI 7, Andrzej WOJTAK 7, Janusz STEC 8, Tomasz URBANEK 9
1 Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland; 2 Outpatient Clinic of Vascular Surgery, Nonpublic Health Care Clinic Mikomed, Łódź, Poland; 3 Department of General and Bariatric Surgery and Emergency Medicine in Zabrze, Medical Faculty with Medical-Dental Division in Zabrze, Medical University of Silesia, Katowice, Poland; 4 Department of Internal Medicine and Angiology, Hospital of the Brothers Hospitallers Order of St. John Grande, Kraków, Poland; 5 Outpatient Clinic of Vascular Surgery, Nonpublic Health Vascular Surgery Centre, Kraków, Poland; 6 Outpatient Clinic of Vascular Surgery, Medical Centre, Wrocław, Poland; 7 Department of Vascular Surgery and Angiology, Medical University, Lublin, Poland; 8 Outpatient Clinic of Vascular Surgery, Medical Centre Kol-Med of the Public Health Care Centre, Tarnów, Poland; 9 Department of General and Vascular Surgery, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland
BACKGROUND: To assess patients’ satisfaction from the therapy of advanced chronic venous disorders (CVD) in everyday clinical practice in Poland, and to compare the efficacy of various venoactive drugs (VADs) in venous ulcers healing process.
METHODS: Seven hundred and eighty unselected adult patients with active (N.=441) or healed (N.=339) venous ulcers participated in the non-interventional observational 6-week study.
RESULTS: Compression therapy and VADs were utilized by 81.5% and 89.2% of patients respectively: 31.2% of all patients underwent surgical procedures for vein incompetence, 61.3% were satisfied with surgical methods, 43% with compression therapy, and 32.6% with VADs ‑ with highest rate of satisfied patients in the group taking Ruscus aculeatus and HMC and ascorbic acid (51.4%). Of 377 patients with active venous ulcers smaller than 200 cm2, adherent to VADs, 18.0% have been cured, and 66.6% have improved during 6-week period of observation. Multiple logistic regression analysis revealed that the compression therapy (OR=2.74), the size of ulcer ≤10 cm2 (OR=2.70) were increasing the change of ulcer healing. No VADs was better than another in the healing process.
CONCLUSION: 1) Compression therapy and VADs are highly utilized by patients with advanced CVD. 2) Patients are more satisfied with surgical than conservative treatment of advanced CVD. 3) More than half of the patients with the advanced stage CVD taking Ruscus aculeatus and HMC and ascorbic acid is satisfied with the obtained improvement. 4) Ruscus aculeatus and HMC and ascorbic acid is similarly effective as other frequently used VADs in venous ulcer healing. 5) Ruscus aculeatus and HMC and ascorbic acid exerting effects on veins, capillaries and lymphatic vessels may explain the positive results observed in this study.