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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2012 June;31(3):252-9
Distribution of brachial-ankle pulse wave velocity values and optimal cut-off in distinguishing subjects with clinical condition in Chinese Population
Wu L. 1, Wang Y. 1, 2, Zheng L. 1, 3, Li J. 1, Hu D. 1, Xu Y. 1, 2, Hasimu B. 4, Yuan H. 5, Yang J. 6, Sun Y. 3, Ma Y. 7 ✉
1 Heart, Lung and Blood Vessel Center Tongji University School of Medicine, Shanghai, China;
2 Department of Cardiology, Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;
3 Department of Cardiology, the First Hospital of China Medical University, Shenyang, China;
4 Heart Centre, the First Affiliation Hospital of Xinjiang Medical University, Urumqi, China;
5 Department of Cardiology, Xiangya Third Hospital of South Central University, Changsha, China;
6 Cardiovascular Center, Fuwai Hospital of Chinese Academy of Medical Science, Beijing, China;
7 Division of Preventive and Behavioral Medicine University of Massachusetts Medical School, Worcester, USA
AIM: The present study aims to examine the distribution and gender- and age-specific reference ranges of brachial-ankle pulse wave velocity (baPWV) in Chinese population.
METHODS: A total of 21094 subjects were recruited into a cross-sectional study from June 2007 to June 2008 in China. Participants were divided into three clinical subgroups: 1) subgroup 1: subjects with atherosclerotic cardiovascular diseases; 2) subgroup 2: subjects with atherosclerotic risk factors; and 3) subgroup 3: “healthy subjects” without any atherosclerotic cardiovascular diseases and atherosclerotic risk factors.
RESULTS: The average baPWV among subgroups one through 3 was 1724.3±429.1, 1603.5±358.8, and 1389.9±288.4 cm/s, respectively. BaPWV did not fit as a normal distribution in both genders. There was no significant difference between male and female for baPWV in subgroup 1 (P>0.05). While baPWV was higher in females than males in subgroup 2, it was lower in females than in males in subgroup 3 (all P<0.05). Notably, BaPWV significantly increased with age in both genders (all P for trend<0.05). The receiver operator characteristic curve demonstrated that a baPWV of 1450 cm/s was useful to discriminate either cardiovascular diseases or atherosclerotic risk factors (sensitivity 62.1%, specificity 69.5%), a baPWV of 1551 cm/s was useful to discriminate cardiovascular diseases (sensitivity 62%, specificity 61%), and a baPWV of 1566 cm/s was useful to discriminate either cardiovascular diseases or chronic kidney disease (sensitivity 60%, specificity 63%).
CONCLUSION: The reference ranges and cut-off values of baPWV can be used to screen atherosclerotic cardiovascular diseases in clinical practices.