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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2011 October;30(5):451-7
A U-shaped relationship between ankle-brachial index and carotid intima-media thickness in a Chinese population of inner Mongolia
Wang Y. 1, Li J. 2, Guo X. 3, Zhao D. 1, Hu D. 2, Wei Y. 1, Hou L. 1, Xu Y. 1, Ma Y. 4 ✉
1 Department of Cardiology, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai, China;
2 Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Shanghai, China;
3 Department of Gastroenterology, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai, China;
4 Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
AIM: The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases.
METHODS: Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampling. ABI and carotid-IMT were measured for each subject. Periphery arterial disease (PAD) was defined as an ABI≤0.9 in either leg. ABI values were divided into eight groups at every 0.05, and three carotid-IMT measures were compared among groups separately using analysis of variance (ANOVA) and multivariate linear regression analyses.
RESULTS: The results indicated that the prevalence of PAD among 1236 participants was 1.9%. The average common carotid IMT was 0.70±0.21 mm, internal carotid IMT 0.77±0.24 mm, and carotid artery bifurcation IMT 0.78±0.25 mm. A U-shaped relationship was observed that the values of common carotid, carotid artery bifurcation, and internal carotid arteries IMT were decreased at first then increased as ABI values increased. The U-shaped relationship between ABI and three carotid-IMT measures were remained after adjusting for covariates.
CONCLUSION: The data suggests that carotid IMT values are correlated with ABI values in a U-shaped curve. Increased carotid IMT is correlated with the high prevalence of PAD in population of Inner Mongolia in China.