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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Wang Y. 1, Li J. 2, Guo X. 3, Zhao D. 1, Hu D. 2, Wei Y. 1, Hou L. 1, Xu Y. 1, Ma Y. 4
1 Department of Cardiology, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai, China;
2 Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Shanghai, China;
3 Department of Gastroenterology, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai, China;
4 Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
AIM: The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases.
METHODS: Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampling. ABI and carotid-IMT were measured for each subject. Periphery arterial disease (PAD) was defined as an ABI≤0.9 in either leg. ABI values were divided into eight groups at every 0.05, and three carotid-IMT measures were compared among groups separately using analysis of variance (ANOVA) and multivariate linear regression analyses.
RESULTS: The results indicated that the prevalence of PAD among 1236 participants was 1.9%. The average common carotid IMT was 0.70±0.21 mm, internal carotid IMT 0.77±0.24 mm, and carotid artery bifurcation IMT 0.78±0.25 mm. A U-shaped relationship was observed that the values of common carotid, carotid artery bifurcation, and internal carotid arteries IMT were decreased at first then increased as ABI values increased. The U-shaped relationship between ABI and three carotid-IMT measures were remained after adjusting for covariates.
CONCLUSION: The data suggests that carotid IMT values are correlated with ABI values in a U-shaped curve. Increased carotid IMT is correlated with the high prevalence of PAD in population of Inner Mongolia in China.