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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2011 August;30(4):380-7
Association between serum nitric oxide metabolites and hypertension in a general population
Ghasemi A., Zahediasl S., Syedmoradi L., Azizi F. ✉
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AIM:Endothelial dysfunction and impaired release of endothelial nitric oxide occurs in hypertension. The aim of this study was to determine the relation between nitric oxide metabolites (NOx) concentrations and blood pressure levels in a general population.
METHODS:In a cross-sectional study, NOx was measured in 2968 adult subjects, randomly selected from a population-based study, using the Griess method. Subjects were classified into normal, prehypertension, stage 1 hypertension and stage two hypertension groups, according to the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure.
RESULTS: Serum NOx values were negatively correlated with systolic blood pressure ≥160 mm Hg in men (r=-0.523, P=0.002). Serum NOx was higher in men with stage 1 hypertension while those with stage 2 hypertension had significantly lower NOx levels. In men, medication increased serum NOx concentration in both stages of hypertension but in women, a significant increase was observed only in stage 1 hypertension.
CONCLUSION: Serum NOx concentrations decreased in untreated stage 2 hypertension and increased in stage 1 hypertension in men, findings that suggest NOx measurement might be helpful for assessing endothelial (dys) function in male hypertensive subjects.