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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2011 Aprile;30(2):164-71
Effects of buflomedil on skin blood flow in patients with type 2 diabetes mellitus without
overt micro- or macroangiopathy
Tsantilas D. 1, Hatzitolios A. I. 2, Tziomalos K. 2, Karamitsos D. 2, Papadimitriou D. 3 ✉
1 Department of Internal Medicine, “Georgios Gennimatas” General Hospital, Thessaloniki, Greece;
2 First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital;
3 Division of Vascular Surgery, Second Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
AIM:The aim of this study was to assess the effects of buflomedil on the peripheral microcirculation in patients with type 2 diabetes mellitus (T2DM) without overt micro- or macroangiopathy.
METHODS: Twenty-three patients with T2DM were randomly assigned to receive buflomedil 600 mg/day for six months (N.=12) or no medication (N.=11). Skin blood flow in the lower limbs was assessed at baseline and after 3 and 6 months using Laser Doppler. We measured the following laser Doppler parameters: volume, flow and velocity.
RESULTS: In patients treated with buflomedil, there was a significant increase in volume (P=0.039) and a trend for an increase in both flow and velocity (P=0.097 for both parameters). In contrast, significant decreases in volume and flow were observed in the control group (P=0.045 and P=0.027, respectively) whereas velocity did not change (P=0.150).
CONCLUSION: In conclusion, buflomedil appears to have a beneficial effect on the peripheral microcirculation in patients with T2DM.