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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2011 Febbraio;30(1):71-8
The clinical importance in differentiating portal from mesenteric venous thrombosis
Acosta S. 1, Alhadad A. 1, Verbaan H. 2, Ögren M. 3 ✉
1 Vascular Centre, Malmö University Hospital, Malmö, Sweden;
2 Department of Medicine, Malmö University Hospital, Malmö, Sweden;
3 Institution of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
AIM: To relate the extent of portomesenteric thrombosis to the risk of intestinal infarction, concomitant venous thromboembolism and underlying diseases.
METHODS: Identification of patients with mesenteric (MVT) and portal vein thrombosis (PVT) at Malmö University Hospital from a clinical series from 2000 – 2006 as well as an autopsy cohort of 24000 consecutive autopsies from 1970 – 1982.
RESULTS: In the clinical comparative study, MVT (n=51) was associated with more thrombophilic disorders (P=0.040) and intestinal infarctions (P=0.046), whereas patients with PVT without extension to the superior mesenteric vein (n=20) more often had liver disease (P<0.001). At autopsy, 270 patients with portomesenteric venous thrombosis were found; twenty-nine out of the 31 cases with MVT had intestinal infarction. None (0%) of the 239 patients with PVT without extension into the superior mesenteric vein had intestinal infarction. Portomesenteric venous thrombosis and intestinal infarction was associated with concomitant venous thromboembolism (O. R. 6.1 [95% CI 1.8-21]).
CONCLUSION: MVT carries a high risk of developing intestinal infarction and is associated with concomitant venous thromboembolism, whereas PVT is associated with liver disease.