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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2006 June;25(2):221-7

Copyright © 2006 EDIZIONI MINERVA MEDICA

lingua: Inglese

The role of endothelin-1 and selected cytokines in the pathogenesis of Raynaud's phenomenon associated with systemic connective tissue diseases

Rychlik-Golema W., Mastej K., Adamiec R.

Department and Clinic of Angiology, Hypertension and Diabetology Medical University of Wroclaw, Wroclaw, Poland


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Aim. In the pathogenesis of Raynaud's phenomenon humoral and immunoinflammatory agents are involved. The aim of this study was the assessment of the level of endothelin-1 (ET-1), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), soluble IL-6 receptor (IL-6sR), von Willebrand’s factor (vWF) and platelet factor 4 (PF-4) in patients with Raynaud’s phenomenon associated with systemic connective tissue diseases.
Methods. The examined group consisted of 32 patients (24 women and 8 men) with Raynaud’s phenomenon associated with selected connective tissue diseases, aged 28-50 years. A control group consisted of 13 healthy volunteers. Immediately after a cold provocation test venous blood was taken in order to assess serum concentrations of: TNF-α, IL-6, IL-6sR, vWF, PF-4, antinuclear antibodies (ANA), antineutrophil antibodies (c-ANCA).
Results. In the group of patients with Raynaud’s phenomenon mean serum concentration of ET-1, TNF-α, PF-4, and vWF was significantly greater than in the healthy group. In contrast, serum IL-6 and IL-6sR concentrations did not differ significantly between the diseased and healthy groups. In a subgroup of Raynaud’s phenomenon patients showing particularly high concentration of serum ET-1 (twice as much as mean control concentration), the increase in IL-6, IL-6sR, vWF and c-ANCA concentration exhibited statistical significance in comparison with patients with lower serum ET-1 concentration. The vWF concentration exhibited positive correlation with time interval between the occurrence of clinical symptoms and serum ANA antibodies concentration. The increase in ET-1 synthesis in Raynaud’s phenomenon patients is dependent on the increase in IL-6 level and c-ANCA antibodies level.
Conclusion. The patients with Raynaud’s phenomenon show an increase in ET-1 and TNF-α concentrations. An enhanced ET-1 synthesis is dependent on the augmentation of serum c-ANCA antibodies and IL-6 concentrations.

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