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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
International Angiology 2004 September;23(3):276-83
Non spiral and spiral (helical) flow patterns in stenoses. In vitro observations using spin and gradient echo magnetic resonance imaging (MRI) and computable fluid dynamic modeling
Stonebridge P. A. 1, Buckley C. 2, Thompson A. 3, Dick J. 4, Hunter G. 5, Chudek J. A. 5, Houston J. G. 3, Belch J. J. F. 4
1 Department of Surgery, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, UK
2 Magnetic Resonance Research Centre, Department of Chemical Engineering, University of Cambridge, Cambridge, UK
3 Department of Radiology, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, UK
4 Department of Vascular Medicine, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, UK
5 Department of Chemistry, Dundee University, Dundee, Scotland, UK
Aim. Physiological blood flow patterns are themselves poorly understood despite their impact on arterial disease. Stable spiral (helical) laminar flow (SLF) has been observed in normal subjects. The purpose of the present study is to develop a method of magnetic resonance (MR) flow pattern visualization and to analyze spiral and non-spiral flow patterns with and without luminal narrowing in vitro. The flow conditions were then modeled using computational fluid dynamics (Star-CD).
Methods. Laminar integrity was examined in a flow-rig using spin and gradient echo magnetic resonance imaging (MRI) in non-stenosed and stenosed conduits in the presence of non-spiral and spiral flow.
Results. No difference was observed in a non-stenosed conduit between non-spiral and spiral flow. In the presence of a stenosis spiral flow preserves flow velocity coherence whereas non-spiral flow increasingly lost coherence beginning proximal to the stenosis. Computational fluid dynamic modeling of the in vitro experiment showed marked differences between the 2 flow patterns. Non-spiral flow produced greater inwardly directed forces just beyond the stenosis and greater outward pressures at more distal sites. The near wall turbulent energy was up to 700% less with spiral flow over non-spiral flow beyond the stenosis.
Conclusion. Spiral flow appears to offer clear flow profile stabilizing advantages over non-spiral flow, by significantly reducing the turbulence caused by a stenosis. Spiral flow also produces lower forces acting on the vessel wall.