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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2004 September;23(3):238-45
The effect of Liple® on physical and emotional quality of life in the treatment of arteriosclerosis obliterans
Fukuhara S. 1, Esato K. 2
1 Department of Epidemiology and Healthcare Research, Kyoto University, Graduate School of Medicine and Public Health, Kyoto, Japan
2 Yamaguchi Prefecture Central Hospital, Yamaguchi, Japan
Aim. The purpose of this study was to determine the effect of treatment with prostaglandin E1, Liple, on both the physical and emotional health-related quality of life (QOL) of patients with arteriosclerosis obliterans (ASO).
Methods. Treatment with Liple was evaluated using the before and after treatment results obtained using the SF-36, a QOL questionnaire, and an assessment of symptoms by a physician. The study was designed as a non-randomized before and after treatment study without comparison groups, and the study was conducted from May 1999 to July 2001 at 473 facilities located within Japan targeting patients with ASO. No intervention other than the administration of Liple was performed, and no restrictions were placed on the dose amount or administration interval for Liple.
Results. The results suggest that there was a significant improvement in patients’ symptoms after treatment with Liple.
Conclusion. Both physical and emotional QOL also improved after admistration of Liple compared to baseline, based on the results of the SF-36 and assessment of symptoms by a physician.