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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2003 December;22(4):414-20

lingua: Inglese

A 16-year survey of Takayasu’s arteritis in a tertiary Belgian center

Ruige J. B., Van Geet C., Nevelsteen A., Verhaeghe R.

Vas­cu­lar Cen­ter, Uni­ver­sity of Leu­ven, Leu­ven, Bel­gium


Aim. To eval­u­ate the clin­i­cal fea­tures, angio­graph­ic find­ings and evo­lu­tion of ­Takayasu’s arter­itis in a Bel­gian ter­tiary cen­ter, and to com­pare the find­ings with pub­lished ­series of West­ern ­patients.
Meth­ods. Ret­ro­spec­tive anal­y­sis of 15 ­patients with ­Takayasu’s arter­itis, sat­is­fy­ing the Amer­i­can Col­lege of Rheu­ma­thol­o­gy cri­te­ria, in the peri­od 1986 to 2002. Pub­lished ­series of West­ern ­patients were iden­ti­fied by means of a Med­line ­search and cita­tion-track­ing.
­Results. Diag­no­sis was often ­delayed, with a ­median peri­od of 9 ­months. ­Patients pre­sent­ed with a varie­ty of symp­toms and clin­i­cal signs and had on aver­age 4.5 arte­ri­al seg­ments ­involved at angio­gra­phy. ­Twelve ­patients ­received cor­ti­cos­ter­oid treat­ment and 4 of them addi­tion­al immu­no­sup­pres­sive drugs. Five ­patients under­went angio­plas­ty and/or stent­ing and 8 ­patients had open sur­gi­cal pro­ce­dures. Dur­ing fol­low-up, there were 2 car­diac ­deaths and 2 other ­patients died from intra­cra­ni­al hem­or­rhage. Com­par­i­son with pub­lished ­series of other West­ern ­patients did not ­reveal major dif­fer­enc­es of ana­tom­i­cal dis­tri­bu­tions of the ­lesions, but left the impres­sion that more aggres­sive use of immu­no­sup­pres­sive drugs might have ­improved the out­come.
Con­clu­sion. ­Takayasu’s arter­itis ­results in an impor­tant mor­bid­ity and mor­tal­ity. More aggres­sive med­i­cal ther­a­py may be advan­ta­geous, but this would ­require ade­quate inves­ti­ga­tion in a con­trolled trial for which a mul­ti­cen­ter ­effort is need­ed ­because of the rar­ity of the dis­ease.

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