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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Periodicità: Bimestrale

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2003 Settembre;22(3):243-9


Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld’s phenomenon and workers with vibration-induced white finger

Nakamura H. 1, Matsuzaki I. 2, Hatta K. 3, Nagase H. 4, Nobokuni Y. 1, Kambayashi Y. 1, Ogino K. 1

1 Depart­ment of Envi­ron­men­tal and Pre­ven­tive Med­i­cine, Grad­u­ate ­School of Med­i­cal Sci­ence, Kan­a­zawa, Japan
2 Insti­tute of Com­mu­nity Med­i­cine, Uni­ver­sity of Tsu­ku­ba, Tsu­ku­ba, Japan
3 Depart­ment of Psy­chi­a­try, Jun­ten­do Uni­ver­sity ­School of Med­i­cine, Tokyo, Japan
4 Depart­ment of Envi­ron­men­tal ­Health, Toy­a­ma Insti­tute of ­Health, Toy­a­ma, Japan

Aim. Cold water-immer­sion induc­es vaso­con­stric­tion with an ele­va­tion of blood endo­the­lin-1, which is a ­potent vas­o­con­stric­tor pep­tide, in ­patients with pri­mary ­Raynaud’s phe­nom­e­non (PRP). How­ev­er, phys­io­log­i­cal involve­ment of endo­the­lin-1 in cold-­induced vasod­i­la­tion (CIVD) ­remains to be elu­ci­dat­ed.
Meth­ods. We mon­i­tored chang­es of fin­ger blood flow dur­ing cold water (10°C) immer­sion and ­assayed blood endo­the­lin-1 in 7 PRP ­patients and 7 work­ers with vibra­tion-­induced white fin­ger (VWF) and in the respec­tive con­trol sub­jects.
­Results. While sig­nif­i­cant reduc­tions in fin­ger blood flow at 2 min after the immer­sion were ­observed in PRP ­patients and VWF work­ers, its ele­va­tion at 4 min, which was con­sid­ered to ­reflect CIVD, was rec­og­nized only in PRP ­patients. In ­healthy con­trols, blood endo­the­lin-1 ­increased at 4 min and ­returned to the basal level imme­di­ate­ly after the immer­sion. The ­increase in blood endo­the­lin-1 at 4 min in PRP ­patients was great­er than that in con­trols, and con­tin­ued even after the immer­sion. Con­verse­ly, the ­increase nei­ther at 4 min nor after immer­sion was seen in VWF work­ers. Local vas­cu­lar chang­es pro­duced by repet­i­tive vibra­tion may be respon­sible for the atten­u­at­ed CIVD and ­unchanged blood endo­the­lin-1 dur­ing cold water-immer­sion in VWF work­ers.
Con­clu­sion. Our ­results show­ing ele­vat­ed blood endo­the­lin-1 dur­ing and after immer­sion in PRP con­trast with that in VWF sug­gest­ing that endo­the­lin-1 is relat­ed to sym­pa­thet­ic hyper­ac­tiv­ity which is more ­involved in PRP rath­er than VWF. It seems unlike­ly that endo­the­lin-1 is func­tion­al­ly or direct­ly asso­ciat­ed with CIVD.

lingua: Inglese


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