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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2003 June;22(2):199-201

lingua: Inglese

Recur­rent epi­sodes of deep vein throm­bo­sis in a young man

Giotopoulou S. 1, Giafis K. 2, Dokou E. 1, Tsaousi C. 1, Kolaitis N. 1, Vartholomatos G. 1

1 Hem­a­tol­o­gy Labor­a­to­ry, Unit of Mocolec­u­lar Biol­o­gy, Uni­ver­sity Hos­pi­tal of Ioan­ni­na, Ioan­ni­na, ­Greece
2 Region­al Hos­pi­tal of Cef­a­lo­nia, Cef­a­lo­nia, ­Greece


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We ­present the case of a 32-year-old man suf­fer­ing from recur­rent epi­sodes of deep vein throm­bo­sis (DVT). He was het­er­o­zy­gous for the G1691A muta­tion in the Fac­tor V gene. His ­father was het­er­o­zy­gous for the same muta­tion and had a ­unique epi­sode of DVT after a frac­ture of the tibia. Genet­ic pre­dis­po­si­tion sig­nif­i­cant­ly influ­enc­es the prev­a­lence of throm­bot­ic ­events, how­ev­er, addi­tion­al ­unknown fac­tors may be ­involved in the initi­a­tion and recur­rence of ­venous throm­boem­bo­lism.

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