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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2003 June;22(2):134-40

lingua: Inglese

Heal­ing pro­cess in anas­tom­o­sis of homol­o­gous ­venous ­grafts pre­served in glu­ta­ral­de­hyde implant­ed aorta of rab­bits

Moura R. 1, Yoshida W. B. 1, Fabris V. E. 2, Angeleli A. Y. O. 3, Naresse L. E. 1, Maffei F. H. A. 1

1 Depart­ment of Sur­gery and Ortho­pe­dics, ­School of Med­i­cine of Pau­lis­ta State Uni­ver­sity, Bot­u­ca­tu, São Paulo, Bra­zil
2 Depart­ment of Pathol­o­gy, ­School of Med­i­cine of Pau­lis­ta State Uni­ver­sity, Bot­u­ca­tu, São Paulo, Bra­zil
3 Depart­ment of Med­i­cine, ­School of Med­i­cin­e­ of Pau­lis­ta State Uni­ver­sity, Bot­u­ca­tu, São Paulo, Bra­zil


Aim. Autol­o­gous vein (AV) is some­times not suit­able or ­present for a vas­cu­lar res­to­ra­tion. Homol­o­gous vein pre­served in glu­ta­ral­de­hyde may be an alter­na­tive to AV, but lit­tle is yet known about this graft and its heal­ing pro­cess after implan­ta­tion in arter­ies. The pur­pose of this study was to com­pare the ­initial heal­ing pro­cess of glu­ta­ral­de­hyde-­tanned homol­o­gous ­venous ­grafts (group 1) with fresh autol­o­gous ­venous ­grafts (group 2), at 4 or 15 days.
Meth­ods. Forty Nor­folk rab­bits were allo­cat­ed in 2 ­groups of 20 ani­mals each. The ­grafts was inter­posed in the infra­ren­al aorta of the rab­bit. Anas­to­mot­ic ten­sile ­strength (TS), hydrox­y­pro­line (HP) deter­mi­na­tion, and his­tol­o­gy (HA) were per­formed.
­Results. TS ­increased in both ­groups, from the 4th to 15th day, (p<0.01) in both prox­i­mal (G1: from 364.5±98.3 g to 491.8±107.3 g; G2: from 366.26±85.15 g to 518.46±82.79 g) and dis­tal anas­tom­o­sis (G1: from 363.53±96.26 g to 507.32±91.01 g; G2: from 352.30±102.41 g to 528.67±48.58 g), with no dif­fer­ence ­between the ­groups. HP did not ­change (p>0.10) in this same peri­od and was sim­i­lar in both ­groups, in the prox­i­mal (G1: from 677.99±153.98 µg/100 mg to 914.92±459.83 µg/100 mg; G2: from 668.65±170.28 µg/100 mg to 669.46±319.80 ug/100 mg) as well as in the dis­tal anas­tom­o­sis (G1: from 740.07±213.53 µg/100 mg to 923.52±270.57 µg/100 mg; G2: from 737.66±266.76 µg/100 mg to 707.68±171.25 µg/100 mg). ­Initial inflam­ma­to­ry and rep­ar­a­tive fea­tures of the anas­tom­o­sis were sim­i­lar in both ­groups.
Con­clu­sion. We can con­clude that the heal­ing pro­cess of the glu­ta­ral­de­hyde-­tanned homol­o­gous vein graft was sim­i­lar to that of the fresh autol­o­gous ­venous graft.

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