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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2003 March;22(1):50-4


lingua: Inglese

Epidemiological characteristics of acute pulmonary thromboembolism in Japan

Yamada N., Nakamura M., Ishikura K., Ota M., Yazu T., Hiraoka N., Tanaka H., Ito M., Fujioka H., Isaka N., Nakano T.

The 1st Department of Internal Medicine, Mie University, Tsu, Japan


Aim. In Japan, acute pul­mo­nary throm­boem­bo­lism (APTE) is still rare, but the num­ber of ­patients with APTE has been stead­i­ly increas­ing. It is impor­tant for early diag­no­sis and early man­age­ment of APTE to rec­og­nize epi­dem­i­olog­i­cal char­ac­ter­is­tics of this con­di­tion.
Meth­ods. We inves­ti­gat­ed the epi­dem­i­olog­i­cal char­ac­ter­is­tics of 252 ­patients with APTE who were admit­ted to our insti­tu­tions ­between 1975 and 2001. APTE was more prev­a­lent in women that in men. It was ­observed the most in the age group ­between 50s to 70s, espe­cial­ly in women. Many ­patients had pro­longed immo­bil­iza­tion, ­recent major oper­a­tion, obes­ity, or can­cer, as risk fac­tors for ­venous throm­boem­bo­lism. One hun­dred and thir­ty-eight ­patients devel­oped APTE in hos­pi­tal; 60 ­patients were in Depart­ment of Inter­nal Med­i­cine, 28 in Gen­er­al Sur­gery, 15 in Ortho­pe­dics, 15 in Obstet­rics and Gyne­col­o­gy, and 20 in other ser­vic­es.
­Results. Among 58 ­patients with malig­nan­cy, 43% had can­cers in diges­tive ­organs, 21% in gyne­co­log­ical, and 17% in uro­log­i­cal. Among 61 patients ­who were exam­ined for the pres­ence of throm­bo­phil­ia, 13 ­patients had inher­it­ed throm­bo­phil­ia (8 pro­tein C defi­cien­cy, 4 pro­tein S defi­cien­cy, and 1 anti­throm­bin III defi­cien­cy) 11 had anti­phos­pho­lip­id anti­bod­ies which indi­cat­ed throm­bo­phil­ia. Five out of the above 61 ­patients (8%) had no obvi­ous risk fac­tors includ­ing throm­bo­phil­ia.
Con­clu­sion. The find­ings in our ­patients were ­almost the same as those in West­ern ­patients, ­except for some ­points. These ­results might be use­ful to estab­lish a pre­ven­tive ­approach for APTE in Japan.

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