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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2003 March;22(1):1-14

Copyright © 2003 EDIZIONI MINERVA MEDICA

lingua: Inglese

Non-invasive exclusion and diagnosis of pulmonary embolism by sequential use of the rapid ELISA D-dimer assay, clinical score and spiral CT

Michiels J. J. 1, Schroyens W. 1, De Backer W. 2, Van Der Planken M. 3, Hoogsteden H. 4, Pattynama P. M. T. 5

1 Hemostasis Thrombosis Research, Department of Hematology, University Hospital, Antwerp, Belgium;
2 Department of Pulmonary Diseases, University Hospital, Antwerp, Belgium;
3 Department of Hemostasis Thrombosis Research, Department of Clinical Biology, University Hospital Antwerp, Belgium;
4 Department of Pulmonary Diseases, Academic Hospital Dijkrigt, Erasmus, University Medical Center, Rotterdam (EMCR), The Netherlands;
5 Department of Radiology, Academic Hospital Dijkrigt, Erasmus, University Medical Center, Rotterdam (EMCR), The Netherlands


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Pulmonary angiography is the gold standard for segmental pulmonary embolism (PE) but no longer for its subsegmental PE, because the inter-observer agreement for angiographically documented subsegmental PE is only 60%. Two non-invasive tools exclude PE with a negative predictive value of >99%: a normal perfusion lung scan and a normal rapid ELISA VIDAS D-dimer test. The positive predictive value of a high probability ventilation-perfusion lung scan (VP-scan) is only 85% to 87%. The combination of a low clinical score and a non-diagnostic VP-scan safely exclude PE without the need of angiography. The prevalence of PE and that of an alternative diagnosis in symptomatic patients with a non-diagnostic VP-scan are 10% to 20% and 30% to 45%, respectively. Helical spiral computed tomography (CT) detects all clinically relevant PE and a large number of alternative diagnoses in symptomatic patients with a non-diagnostic or high probability VP-scan. The positive predictive value of the spiral CT is >95%. Single-slice helical CT as the primary diagnostic test in patients with suspected PE in retrospective outcome studies and in prospective multicenter management studies indicate that the negative predictive value of a negative spiral CT preceded or followed by a negative compression ultrasonography (CUS) is >99%. Therefore, a helical spiral CT can replace both the VP-scan and pulmonary angiography to safely rule in and out PE. A negative rapid ELISA VIDAS D-dimer test result will reduce the need for helical spiral CT by 25% to 35%.

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