I TUOI DATI
I TUOI ORDINI
N. prodotti: 0
Totale ordine: € 0,00
I TUOI ABBONAMENTI
I TUOI ARTICOLI
Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
International Angiology 2002 Giugno;21(2):152-7
The stiffness of the common carotid artery in patients with Graves’ disease
Czarkowski M., Hilgertner L. *, Powalowski T. **, Radomski D. ***
Chair and Department of Internal Medicine and Endocrinology and
* Chair and Department of General and Thoracic Surgery, University Medical School of Warsaw, Warsaw, Poland
** Institute of Fundamental Technological Research, Polish Academy of Science, Warsaw, Poland
*** Institute of Control and Computation Engineering, Warsaw University of Technology, Warsaw, Poland
Background. Thyroid hormone excess is accompanied by many cardiovascular symptoms. We hypothesised that mechanical properties of the large arteries are also involved in hyperthyroidism-induced cardiovascular changes and set out to investigate this further.
Methods. We compared 2 groups: one composed of hospitalized patients with newly diagnosed, non-treated Graves’ disease (Graves’ group) and the other (control group) composed of healthy persons or patients with euthyroid goiter (n=25 and n=23, respectively). We determined values of cross-sectional compliance (CC100), distensibility (DC100) and stiffness coefficients (α100) estimated for blood pressure Pn=100 mmHg by measuring the blood pressure with the oscillometric method and measuring differences in the diameter of the common carotid artery with ultrasonographic vascular echo Doppler system.
Results. We found no differences in CC100 (10.6 vs 10.3 10-4m2/Mpa), DC100 (29.7 vs 29.6 1/Mpa) or α100 (2.67 vs 2.72) between the 2 groups. However, there were strong correlations between all stiffness parameters and plasma thyroid hormone concentrations in the Graves’ group (rs=0.4698, p<0.001 for DC100, rs=0.4342, p<0.003 for CC100, rs=-0.4698, p<0.001 for α100 and fT3, respectively). This relationships remained significant after statistical corrections for age and lipid levels (rp=0.22, p<0.03 for DC100 and fT3 or rp=-0.457, p<0.02 for α100 and fT3, respectively).
Conclusions. These results indicate that in the Graves’ group the stiffness of the common carotid artery might be affected by the thyroid hormone level and the lower the level, the more severe the activity of the hyperthyroidism reflected by the plasma concentration of fT3 or fT4.