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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Periodicità: Bimestrale

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2002 Giugno;21(2):152-7


The stiffness of the common carotid artery in patients with Graves’ disease

Czarkowski M., Hilgertner L. *, Powalowski T. **, Radomski D. ***

Chair and Department of Internal Medicine and Endocrinology and
* Chair and Department of General and Thoracic Surgery, University Medical School of Warsaw, Warsaw, Poland
** Institute of Fundamental Technological Research, Polish Academy of Science, Warsaw, Poland
*** Institute of Control and Computation Engineering, Warsaw University of Technology, Warsaw, Poland

Background. Thyroid hor­mone ­excess is accom­pa­nied by many car­di­o­vas­cu­lar symp­toms. We hypo­the­sised that mechan­i­cal prop­er­ties of the large arter­ies are also ­involved in hyper­thyr­oi­dism-­induced car­di­o­vas­cu­lar chang­es and set out to inves­ti­gate this fur­ther.
Methods. We com­pared 2 ­groups: one com­posed of hos­pit­al­ized ­patients with newly diag­nosed, non-treat­ed Graves’ dis­ease (Graves’ group) and the other (con­trol group) com­posed of ­healthy per­sons or ­patients with euthyr­oid goi­ter (n=25 and n=23, respec­tive­ly). We deter­mined val­ues of cross-sec­tion­al com­pli­ance (CC100), dis­ten­sibil­ity (DC100) and stiff­ness coef­fi­cients (α100) esti­mat­ed for blood pres­sure Pn=100 mmHg by meas­ur­ing the blood pres­sure with the oscil­lo­met­ric meth­od and meas­ur­ing dif­fer­enc­es in the diam­e­ter of the com­mon carot­id ­artery with ultra­son­o­graph­ic vascular echo Doppler ­system.
Results. We found no dif­fer­enc­es in CC100 (10.6 vs 10.3 10-4m2/Mpa), DC100 (29.7 vs 29.6 1/Mpa) or α100 (2.67 vs 2.72) ­between the 2 ­groups. However, there were ­strong cor­re­la­tions ­between all stiff­ness param­e­ters and plas­ma thy­roid hor­mone con­cen­tra­tions in the Graves’ group (rs=0.4698, p<0.001 for DC100, rs=0.4342, p<0.003 for CC100, rs=-0.4698, p<0.001 for α100 and fT3, respec­tive­ly). This rela­tion­ships ­remained sig­nif­i­cant after sta­tis­ti­cal cor­rec­tions for age and lipid lev­els (rp=0.22, p<0.03 for DC100 and fT3 or rp=-0.457, p<0.02 for α100 and fT3, respec­tive­ly).
Conclusions. These ­results indi­cate that in the Graves’ group the stiff­ness of the com­mon carot­id ­artery might be affect­ed by the thy­roid hor­mone level and the lower the level, the more ­severe the activ­ity of the hyper­thyr­oi­dism reflect­ed by the plas­ma con­cen­tra­tion of fT3 or fT4.

lingua: Inglese


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