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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2001 June;20(2):148-51

lingua: Inglese

The PIA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis

Renner W., Winkler M., Hoffmann C., Köppel H., Brodmann M., Pilger E.

From the Divi­sion of Angi­ol­o­gy, Depart­ment of Med­i­cine, Uni­ver­sity Hospital, Graz, Aus­tria


Back­ground. Plate­let gly­co­pro­tein (GP) IIb/IIIa, a fibrino­gen and von Wille­brand fac­tor bind­ing mem­brane recep­tor, has an impor­tant role in plate­let aggre­ga­tion. A com­mon leu­cine33-pro­line poly­mor­phism (PlA1/A2) of the gene encod­ing the GP IIIa sub­unit is asso­ciat­ed with plate­let reac­tiv­ity and has been pro­posed as a risk fac­tor for ath­e­roth­rom­bot­ic dis­ease. The aim of this study was to inves­ti­gate the role of this poly­mor­phism for deep ­venous throm­bo­sis (DVT).
Meth­ods. We per­formed a case-con­trol study includ­ing 206 ­patients with doc­u­ment­ed DVT and a sex- and age-­matched group of 310 con­trol sub­jects. GP IIIa gen­o­types were deter­mined by restric­tion frag­ment anal­y­sis of amplim­ers con­tain­ing the poly­mor­phic site.
­Results. A1/A1, A1/A2 and A2/A2 gen­o­types were found in 67.0, 31.6 and 1.5% of ­patients and 72.3, 25.8 and 1.9% of con­trols (p=0.35), PlA2 ­allele fre­quen­cies were 0.17 in ­patients and 0.15 in con­trols (p=0.92). Odds ratio of the PlA2 ­allele for DVT was 1.21 (95% CI 0.85-1.71, p=0.29) and ­remained insig­nif­i­cant after adjust­ment for fac­tor V Leid­en and pro­throm­bin 20210A gen­o­types (1.22, 95% CI 0.86-1.75, p=0.27).
Con­clu­sions. Our data sug­gest that the PlA1/A2 poly­mor­phism of GP IIIa is not asso­ciat­ed with DVT.

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