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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2001 June;20(2):148-51
The PIA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis
Renner W., Winkler M., Hoffmann C., Köppel H., Brodmann M., Pilger E.
From the Division of Angiology, Department of Medicine, University Hospital, Graz, Austria
Background. Platelet glycoprotein (GP) IIb/IIIa, a fibrinogen and von Willebrand factor binding membrane receptor, has an important role in platelet aggregation. A common leucine33-proline polymorphism (PlA1/A2) of the gene encoding the GP IIIa subunit is associated with platelet reactivity and has been proposed as a risk factor for atherothrombotic disease. The aim of this study was to investigate the role of this polymorphism for deep venous thrombosis (DVT).
Methods. We performed a case-control study including 206 patients with documented DVT and a sex- and age-matched group of 310 control subjects. GP IIIa genotypes were determined by restriction fragment analysis of amplimers containing the polymorphic site.
Results. A1/A1, A1/A2 and A2/A2 genotypes were found in 67.0, 31.6 and 1.5% of patients and 72.3, 25.8 and 1.9% of controls (p=0.35), PlA2 allele frequencies were 0.17 in patients and 0.15 in controls (p=0.92). Odds ratio of the PlA2 allele for DVT was 1.21 (95% CI 0.85-1.71, p=0.29) and remained insignificant after adjustment for factor V Leiden and prothrombin 20210A genotypes (1.22, 95% CI 0.86-1.75, p=0.27).
Conclusions. Our data suggest that the PlA1/A2 polymorphism of GP IIIa is not associated with DVT.