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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2001 June;20(2):126-30

lingua: Inglese

Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients

Migdalis I. N., Varvarigos N., Charalabides J., Leontiades E., Gerolimou B., Mantzara F., Karmaniolas K.

From the Depart­ment of Dia­betes, NIMTS Hos­pi­tal, Ath­ens, ­Greece

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Back­ground. An ­increased thick­ness of the carot­id ­artery wall is ­thought to be a sign of early ath­ero­scler­o­sis. We have inves­ti­gat­ed the ­effect of early treat­ment with buflom­e­dil on the pre­ven­tion of the arte­ri­al wall thick­en­ing.
Meth­ods. ­Eighty ­patients with Type 2 dia­betes were stud­ied. Oral buflom­e­dil (600 mg once daily) was admin­is­tered for 12 ­months in 42 ­patients ran­dom­ly select­ed, while 38 ­received no treat­ment. The two ­groups were ­matched for age, sex, body mass index (BMI), dura­tion of dia­betes and gly­caem­ic con­trol. Arte­ri­al wall thick­ness was meas­ured as the mean of the max­i­mum inti­ma media thick­ness (IMT) in 8 carot­id seg­ments meas­ured by B-mode ultra­sound.
­Results. Blood pres­sure and lipid lev­els ­remained ­unchanged in the two stud­ied ­groups while no dif­fer­ence was found in meta­bol­ic con­trol ­between them. The IMT ­increase over 12 ­months was 0.04 mm in the buflom­e­dil group where­as in that with­out buflom­e­dil it was 0.10 mm.
Con­clu­sions. We con­clude that buflom­e­dil treat­ment may be use­ful in decreas­ing the pro­gres­sion rate of arte­ri­al wall thick­ness.

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