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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2001 June;20(2):118-25


lingua: Inglese

The intima media thickness and coronary risk factors

Hurwitz Eller N. *°, Netterstrøm B. *

From the * Clinic of Occupational Medicine, ° Department of Clinical Physiology, Hillerød Hospital, Hillerød, Denmark


Background. Aim: to esti­mate the ­degree of ath­ero­scler­o­sis in the carot­ids with dif­fer­ent meas­ure­ments of the inti­ma media thick­ness (IMT), ­obtained by ultra­sound and to ana­lyze the cor­re­la­tions of these meas­ures to cor­o­nary risk fac­tors.
Methods. Design and par­tic­i­pants: 130 ­employed men and women vol­un­teered after pub­lic announce­ment. Measures: ­health and life-style were chart­ed using a com­pre­hen­sive ques­tion­naire. Anthropometric meas­ure­ments, and blood pres­sure after 10 min­ of rest were ­obtained at clin­i­cal exam­ina­tion. Blood tests includ­ed anal­y­ses for fibrino­gen, cho­les­te­rol, and HDL-cho­les­te­rol. The IMT was meas­ured bilat­er­al­ly three times at the tran­si­tion of a. car­o­tis to bul­bus as well as on a. car­o­tis 0.5 cm prox­i­mal there­to. Analyses were con­duct­ed with four method­o­log­i­cally dif­fer­ent ways of express­ing IMT as the depen­dent var­i­able: IMT(left), IMT(com­mu­nis), IMT(mean) and IMT(max).
Results. Among the meas­ure­ments of IMT, IMT(max) ­showed the strong­est cor­re­la­tions to cor­o­nary risk fac­tors, sig­nif­i­cant­ly asso­ciat­ed with sex and age. In uni­var­i­ate anal­y­ses only the ­degree of phys­i­cal activ­ity in the lei­sure time cor­re­lat­ed sig­nif­i­cant­ly to IMT(max) among men. When adjust­ed for age, HDL-cho­les­te­rol, BMI, sys­tol­ic blood pres­sure and phys­i­cal activ­ity in lei­sure time in a mul­ti­ple lin­e­ar regres­sion anal­y­sis IMT(max) ­showed sig­nif­i­cant cor­re­la­tions to phys­i­cal activ­ity in lei­sure time and sys­tol­ic blood pres­sure among men older than 45 years. Among women IMT(max) was sig­nif­i­cant­ly cor­re­lat­ed to HDL-cho­les­te­rol (inverse­ly), which ­remained sig­nif­i­cant in the mul­ti­ple regres­sion anal­y­sis includ­ing the same fac­tors as for men.
Conclusions. IMT(max) among four meas­ures of IMT ­showed the strong­est asso­ci­a­tions to cor­o­nary risk fac­tors in oth­er­wise ­healthy indi­vid­u­als.

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